{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:09:42Z","timestamp":1791086982690,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,5,1]]},"DOI":"10.1095\/biolreprod64.5.1422","type":"journal-article","created":{"date-parts":[[2005,10,31]],"date-time":"2005-10-31T23:33:39Z","timestamp":1130801619000},"page":"1422-1431","source":"Crossref","is-referenced-by-count":29,"title":["Status of p53, p21, mdm2, pRb Proteins, and DNA Methylation in Gonocytes of Control and \u03b3-Irradiated Rats During Testicular Development1"],"prefix":"10.1093","volume":"64","author":[{"given":"Ste\u0301phanie G.","family":"More\u0301no","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Dutrillaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herve\u0301","family":"Coffigny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224185538_R1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/ar.1092030408","article-title":"Proliferation of Sertoli cells in fetal and postnatal rats: a quantitative autoradiographic study","volume":"203","year":"1982","journal-title":"Anat Rec"},{"key":"key\n\t\t\t\t20170224185538_R2","first-page":"511","article-title":"Radiosensitivity of male germ cells in neonatal rats","volume":"4","year":"1962","journal-title":"Int J Rad Biol"},{"key":"key\n\t\t\t\t20170224185538_R3","first-page":"589","article-title":"Continuous and acute irradiation effects on developing animals.","year":"1969","journal-title":"Radiation Biology of the Fetal and Juvenile Mammal, USAEC 17 Symposium Series"},{"key":"key\n\t\t\t\t20170224185538_R4","doi-asserted-by":"crossref","first-page":"8493","DOI":"10.1073\/pnas.92.18.8493","article-title":"P53 controls both the G2\/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts","volume":"92","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224185538_R5","first-page":"109","article-title":"Evidence for a second cell cycle block at G2\/M by p53","volume":"10","year":"1995","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170224185538_R6","doi-asserted-by":"crossref","first-page":"15209","DOI":"10.1073\/pnas.93.26.15209","article-title":"DNA damage and p53-mediated cell cycle arrest: a reevaluation","volume":"93","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224185538_R7","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1093\/emboj\/16.9.2262","article-title":"An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesis","volume":"16","year":"1997","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20170224185538_R8","first-page":"2499","article-title":"Expression of p53 in normal and \u03b3-irradiated rat testis suggests a role for p53 in meiotic recombination and repair","volume":"12","year":"1996","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170224185538_R9","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/sj.cdd.4400396","article-title":"The role of the tumor suppressor p53 in spermatogenesis","volume":"5","year":"1998","journal-title":"Cell Death Differ"},{"key":"key\n\t\t\t\t20170224185538_R10","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/j.1460-2075.1993.tb05678.x","article-title":"mdm2 expression is induced by wild type p53 activity","volume":"12","year":"1993","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20170224185538_R11","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/387296a0","article-title":"Mdm2 promotes the rapid degradation of p53","volume":"387","year":"1997","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224185538_R12","doi-asserted-by":"crossref","first-page":"6937","DOI":"10.1073\/pnas.96.12.6937","article-title":"P19ARF stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2","volume":"96","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224185538_R13","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0092-8674(00)80416-X","article-title":"DNA damage-induced phosphorylation of p53 alleviates inhibition by mdm2","volume":"91","year":"1997","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224185538_R14","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0092-8674(92)90518-H","article-title":"D-type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA","volume":"71","year":"1992","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224185538_R15","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1091\/mbc.6.4.387","article-title":"Inhibition of cyclin dependent kinases by p21","volume":"6","year":"1995","journal-title":"Mol Biol Cell"},{"key":"key\n\t\t\t\t20170224185538_R16","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3181\/00379727-213-44046","article-title":"p21-negative regulator of the cell cycle","volume":"213","year":"1996","journal-title":"Proc Soc Exp Biol Med"},{"key":"key\n\t\t\t\t20170224185538_R17","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(93)90500-P","article-title":"WAF1, a potential mediator of p53 tumor suppression","volume":"75","year":"1993","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224185538_R18","first-page":"1169","article-title":"WAF1\/CIP1 is induced in p53-mediated G1 arrest and apoptosis","volume":"54","year":"1994","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170224185538_R19","first-page":"3391","article-title":"Induction of WAF1\/CIP1 by a p53-independent pathway","volume":"54","year":"1994","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170224185538_R20","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1101\/gad.9.8.935","article-title":"P53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage","volume":"9","year":"1995","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20170224185538_R21","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1006\/excr.1999.4403","article-title":"UV radiation is a transcriptional inducer of p21 (Cip1\/Waf1) cyclin-kinase inhibitor in a p53-independent manner","volume":"248","year":"1999","journal-title":"Exp Cell Res"},{"key":"key\n\t\t\t\t20170224185538_R22","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/(SICI)1098-2795(199707)47:3<240::AID-MRD2>3.0.CO;2-L","article-title":"P21(Cip1\/WAF1) expression in the mouse testis before and after X irradiation","volume":"47","year":"1997","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20170224185538_R23","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0092-8674(91)90181-W","article-title":"The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle","volume":"67","year":"1991","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224185538_R24","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/360177a0","article-title":"Abrogation by c-myc of G1 phase arrest induced by RB protein but not by p53","volume":"360","year":"1992","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224185538_R25","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/0092-8674(92)90249-C","article-title":"Regulation of retinoblastoma protein functions by ectopic expression of human cyclins","volume":"70","year":"1992","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224185538_R26","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/0092-8674(91)90557-F","article-title":"The E2F transcription factor is a cellular target from the RB protein","volume":"65","year":"1991","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224185538_R27","doi-asserted-by":"crossref","first-page":"6474","DOI":"10.1073\/pnas.86.17.6474","article-title":"Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein","volume":"86","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224185538_R28","first-page":"500","article-title":"Expression of the retinoblastoma protein is regulated in normal human tissues","volume":"144","year":"1994","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20170224185538_R29","first-page":"1214","article-title":"Transcriptional rate and steady-state changes of retinoblastoma mRNA in regenerating rat liver","volume":"19","year":"1994","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20170224185538_R30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0303-7207(97)00129-9","article-title":"Stage-specific expression and phosphorylation of retinoblastoma protein (pRb) in the rat seminiferous epithelium","volume":"132","year":"1997","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20170224185538_R31","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0959-437X(05)80052-8","article-title":"Role of DNA methylation in the regulation of transcription","volume":"4","year":"1994","journal-title":"Curr Opin Genet Dev"},{"key":"key\n\t\t\t\t20170224185538_R32","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1074\/jbc.270.2.788","article-title":"Epigenetic gene inactivation induced by a cis-acting methylation center","volume":"270","year":"1995","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224185538_R33","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000015460","article-title":"Alterations of DNA methylation patterns in germ and Sertoli cells from developing mouse testis","volume":"87","year":"1999","journal-title":"Cytogenet Cell Genet"},{"key":"key\n\t\t\t\t20170224185538_R34","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s004180050367","article-title":"The Feulgen reaction 75 years on","volume":"111","year":"1999","journal-title":"Histochem Cell Biol"},{"key":"key\n\t\t\t\t20170224185538_R35","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1177\/39.6.1709656","article-title":"Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections","volume":"39","year":"1991","journal-title":"J Histochem Cytochem"},{"key":"key\n\t\t\t\t20170224185538_R36","first-page":"255","article-title":"Monitoring of urinary excretion of modified nucleosides in cancer patients using a set of six monoclonal antibodies","volume":"61","year":"1991","journal-title":"Cancer Lett"},{"key":"key\n\t\t\t\t20170224185538_R37","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","year":"1976","journal-title":"Anal Biochem"},{"key":"key\n\t\t\t\t20170224185538_R38","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1128\/MCB.19.5.3842","article-title":"Mitochondrial regulation of cell death: mitochondria are essential for procaspase 3-p21 complex formation to resist Fas-mediated cell death","volume":"19","year":"1999","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20170224185538_R39","first-page":"2055","article-title":"Nuclear localization is essential for the activity of p53 protein","volume":"6","year":"1991","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170224185538_R40","first-page":"661","article-title":"Involvement of wild-type p53 protein in the cell cycle requires nuclear localization","volume":"2","year":"1991","journal-title":"Cell Growth Differ"},{"key":"key\n\t\t\t\t20170224185538_R41","doi-asserted-by":"crossref","first-page":"16202","DOI":"10.1074\/jbc.275.21.16202","article-title":"Death signal-induced localization of p53 protein to mitochondria","volume":"275","year":"2000","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224185538_R42","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1093\/emboj\/18.21.6027","article-title":"p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2","volume":"18","year":"1999","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20170224185538_R43","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/(SICI)1521-1878(199905)21:5<402::AID-BIES7>3.0.CO;2-B","article-title":"Eukaryotic DNA methylation as an evolutionary device","volume":"21","year":"1999","journal-title":"Bioessays"},{"key":"key\n\t\t\t\t20170224185538_R44","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1126\/science.140.3566.490","article-title":"X-ray sensitivity and DNA synthesis in synchronous populations of HeLa cells","volume":"140","year":"1963","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224185538_R45","doi-asserted-by":"crossref","first-page":"450","DOI":"10.2307\/3572025","article-title":"X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells","volume":"29","year":"1966","journal-title":"Radiat Res"},{"key":"key\n\t\t\t\t20170224185538_R46","first-page":"1707","article-title":"Subcellular distribution of the p53 protein during the cell cycle of Balb\/c 3T3 cells","volume":"5","year":"1990","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170224185538_R47","first-page":"50","article-title":"Checking on the cell cycle","volume":"30","year":"1998","journal-title":"J Cell Biochem Suppl"},{"key":"key\n\t\t\t\t20170224185538_R48","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1006\/bbrc.1997.6867","article-title":"p53 is associated with the nuclear envelope in mouse testis","volume":"235","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170224185538_R49","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1095\/biolreprod61.6.1541","article-title":"Apoptosis is physiologically restricted to a specialized cytoplasmic compartment in rat spermatids","volume":"61","year":"1999","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224185538_R50","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/dbio.1993.1230","article-title":"Stabilization and expression of high levels of p53 during early development in Xenopus laevis.","volume":"159","year":"1993","journal-title":"Dev Biol"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/64\/5\/1422\/10602288\/biolreprod1422.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T22:01:27Z","timestamp":1554328887000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod64.5.1422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5,1]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,5,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod64.5.1422","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,5,1]]}}}