{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:48:10Z","timestamp":1791157690864,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,3,1]]},"DOI":"10.1095\/biolreprod66.3.562","type":"journal-article","created":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T19:13:41Z","timestamp":1132254821000},"page":"562-567","source":"Crossref","is-referenced-by-count":63,"title":["Promoting Effect of \u03b2-Mercaptoethanol on In Vitro Development under Oxidative Stress and Cystine Uptake of Bovine Embryos1"],"prefix":"10.1093","volume":"66","author":[{"given":"M.","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Okamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Okano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224211909_R1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/217465a0","article-title":"Effect of oxygen concentration on the development of two-cell mouse embryos","volume":"217","year":"1968","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224211909_R2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0093-691X(88)90037-4","article-title":"Role of oviductal secretions in embryonic growth in vivo and vitro","volume":"29","year":"1988","journal-title":"Theriogenology"},{"key":"key\n\t\t\t\t20170224211909_R3","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1530\/jrf.0.0890573","article-title":"Effect of oxygen concentration on in-vitro development of preimplantation sheep and cattle embryos","volume":"89","year":"1990","journal-title":"J Reprod Fertil"},{"key":"key\n\t\t\t\t20170224211909_R4","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/0093-691X(92)90109-5","article-title":"Effect of gas atmosphere on the development of one-cell bovine embryos in two culture systems","volume":"37","year":"1992","journal-title":"Theriogenology"},{"key":"key\n\t\t\t\t20170224211909_R5","doi-asserted-by":"crossref","first-page":"854","DOI":"10.2527\/jas1977.445854x","article-title":"Successful culture in vitro of swine embryos to the blastocyst stage","volume":"44","year":"1977","journal-title":"J Anim Sci"},{"key":"key\n\t\t\t\t20170224211909_R6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0891-5849(93)90126-F","article-title":"Increased generation of reactive oxygen species in embryos cultured in vitro","volume":"15","year":"1993","journal-title":"Free Radical Biol Med"},{"key":"key\n\t\t\t\t20170224211909_R7","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/mrd.1080280408","article-title":"Improvement of superoxide radicals in mouse two-cell block phenomenon","volume":"28","year":"1991","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20170224211909_R8","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1095\/biolreprod49.2.228","article-title":"Effect of thiol compounds on in vitro development and intracellular glutathione content of bovine embryos","volume":"49","year":"1993","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224211909_R9","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0093-691X(99)00278-2","article-title":"The importance of having high glutathione (GSH) level after bovine in vitro maturation on embryo development effect of beta-mercaptoethanol, cysteine and cystine","volume":"53","year":"2000","journal-title":"Theriogenology"},{"key":"key\n\t\t\t\t20170224211909_R10","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1262\/jrd.40.355","article-title":"Effect of \u03b2-mercaptoethanol on the preimplantation development of bovine embryos fertilized in vitro","volume":"40","year":"1994","journal-title":"J Reprod Dev"},{"key":"key\n\t\t\t\t20170224211909_R11","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1095\/biolreprod55.5.1179","article-title":"\u03b2-Mercaptoethanol enhances blastocyst formation rate of bovine in vitro-matured\/in vivo-fertilized embryos","volume":"55","year":"1996","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224211909_R12","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0093-691X(96)00165-3","article-title":"Intracytoplasmic glutathione concentration and the role of \u03b2-mercaptoethanol in preimplantation development of bovine embryos","volume":"46","year":"1996","journal-title":"Theriogenology"},{"key":"key\n\t\t\t\t20170224211909_R13","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/(SICI)1098-2795(199612)45:4<451::AID-MRD7>3.0.CO;2-Q","article-title":"Stimulation of glutathione synthesis of in vitro matured bovine oocytes and its effect on embryo development and freezability","volume":"45:","year":"1996","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20170224211909_R14","doi-asserted-by":"crossref","first-page":"12387","DOI":"10.1016\/S0021-9258(18)43284-X","article-title":"Mechanism of growth stimulation of L1210 cells by 2-mercaptoethanol in vitro","volume":"256:","year":"1981","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224211909_R15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0014-4835(91)90075-P","article-title":"Age-related cysteine uptake as rate limiting in glutathione synthesis and glutathione half-life in the cultured human lens","volume":"53","year":"1991","journal-title":"Exp Eye Res"},{"key":"key\n\t\t\t\t20170224211909_R16","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3168\/jds.S0022-0302(98)75586-9","article-title":"Promotion of development of bovine embryos produced in vitro by addition of cysteine and \u03b2-mercaptoethanol to a chemically defined culture medium","volume":"81","year":"1998","journal-title":"J Dairy Sci"},{"key":"key\n\t\t\t\t20170224211909_R17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1073\/pnas.72.1.73","article-title":"Sulfhydryl dependence in primary explant hematopoietic cells. Inhibition of growth in vitro with vitamin B12 compounds","volume":"72","year":"1975","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224211909_R18","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1111\/j.1471-4159.1993.tb09801.x","article-title":"Cystine uptake and glutathione level in fetal brain cells in primary culture and in suspension","volume":"61","year":"1993","journal-title":"J Neurochem"},{"key":"key\n\t\t\t\t20170224211909_R19","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1432-1033.1991.tb16263.x","article-title":"Eck H-P, Dro\u0308ge W. Low membrane transport and mitogenically stimulated human lymphocyte preparations and human T cell clones","volume":"201","year":"1991","journal-title":"Eur J Biochem"},{"key":"key\n\t\t\t\t20170224211909_R20","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/0093-691X(86)90143-3","article-title":"Bovine in vitro fertilization with frozen thawed semen","volume":"25","year":"1986","journal-title":"Theriogenology"},{"key":"key\n\t\t\t\t20170224211909_R21","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1095\/biolreprod12.2.260","article-title":"Capacitation of rabbit spermatozoa","volume":"12","year":"1975","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224211909_R22","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1530\/jrf.0.0300493","article-title":"Successful culture in vitro sheep and cattle ova","volume":"30","year":"1972","journal-title":"J Reprod Fertil"},{"key":"key\n\t\t\t\t20170224211909_R23","doi-asserted-by":"crossref","first-page":"7558","DOI":"10.1016\/S0021-9258(18)35980-5","article-title":"Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine(S-n-butyl homocysteine sulfoximine)","volume":"254","year":"1979","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224211909_R24","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0015-0282(16)60688-X","article-title":"The toxic effect of short exposure to the atmospheric oxygen concentration on early mouse embryonic development","volume":"51","year":"1989","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20170224211909_R25","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/jez.1402060108","article-title":"The effect of oxygen on the development of preimplantation mouse embryos in vitro","volume":"206","year":"1978","journal-title":"J Exp Zool"},{"key":"key\n\t\t\t\t20170224211909_R26","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1095\/biolreprod43.3.404","article-title":"Environmental variables influencing in vitro development of hamster 2-cell embryos to the blastocyst stage","volume":"43","year":"1990","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224211909_R27","first-page":"749","article-title":"Effect of \u03b2-mercaptoethanol on DNA synthesis in bovine embryos","volume":"67:","year":"1996","journal-title":"Anim Sci Technol (Jpn)"},{"key":"key\n\t\t\t\t20170224211909_R28","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/jcp.1041070215","article-title":"Mechanism of growth promotion of mouse lymphoma L1210 cells in vitro by feeder layer or 2-mercaptoethanol","volume":"107","year":"1981","journal-title":"J Cell Physiol"},{"key":"key\n\t\t\t\t20170224211909_R29","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0008-8749(83)90060-6","article-title":"Mechanism of augmentation of the antibody response in vitro by 2-mercaptoethanol in murine lymphocytes","volume":"79","year":"1983","journal-title":"Cell Immunol"},{"key":"key\n\t\t\t\t20170224211909_R30","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1432-1033.1992.tb17421.x","article-title":"Effect of 2-mercaptoethanol on glutathione levels, cystine uptake and insulin secretion in insulin-secreting cells","volume":"210","year":"1992","journal-title":"Eur J Biochem"},{"key":"key\n\t\t\t\t20170224211909_R31","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1146\/annurev.bi.45.070176.003015","article-title":"Glutathione and related g-glutamyl compounds: biosynthesis and utilization","volume":"45","year":"1976","journal-title":"Annu Rev Biochem"},{"key":"key\n\t\t\t\t20170224211909_R32","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0093-691X(00)00332-0","article-title":"Effect of oxidative stress on development and DNA damage in in-vitro cultured bovine embryos by comet assay","volume":"54","year":"2000;","journal-title":"Theriogenology"},{"key":"key\n\t\t\t\t20170224211909_R33","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/0006-2952(88)90176-1","article-title":"Ecker K-G, Wilmanns W. Promotion of cystine uptake and its utilization for glutathione biosynthesis induced by cysteamine and N-acetylcysteine","volume":"37","year":"1988","journal-title":"Biochem Pharmacol"},{"key":"key\n\t\t\t\t20170224211909_R34","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1095\/biolreprod59.2.431","article-title":"Glutathione is present in reproductive tract secretions and improves development of mouse embryos after chemically induced glutathione depletion","volume":"59","year":"1998","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224211909_R35","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/0006-291X(79)92110-7","article-title":"Cysteine as a system-specific substrate for transport system ASC in rat hepatocytes","volume":"88","year":"1979","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170224211909_R36","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1016\/S0021-9258(19)85901-X","article-title":"Transport interaction of L-cystine and L-glutamate in human diploid fibroblasts in culture","volume":"255","year":"1980","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224211909_R37","first-page":"5563","article-title":"Contrasts in transport systems for amino acids in hepatocytes and a hepatoma cell line HTC","volume":"257","year":"1982","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224211909_R38","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0014-4827(87)90305-3","article-title":"Tsan M-F. Modulation of intracellular glutathione concentrations alters lymphocyte activation and proliferation","volume":"170","year":"1987","journal-title":"Exp Cell Res"},{"key":"key\n\t\t\t\t20170224211909_R39","first-page":"36","article-title":"Intracellular glutathione levels regulate Fos\/Jun induction and activation of glutathione S-transferase gene expression","volume":"54","year":"1994","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170224211909_R40","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.4049\/jimmunol.143.6.1974","article-title":"Cell cycle progression of glutathione-depleted human peripheral blood mononuclear cells is inhibited at S phase","volume":"143","year":"1989","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170224211909_R41","doi-asserted-by":"crossref","first-page":"13519","DOI":"10.1016\/S0021-9258(18)80027-8","article-title":"Liang S-M. Glutathione regulates interleukin-2 activity on cytotoxic T-cells","volume":"264:","year":"1989","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224211909_R42","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1002\/eji.1830260530","article-title":"Fas-mediated apoptosis is modulated by intracellular glutathione in human T cells","volume":"26","year":"1996","journal-title":"Eur J Immunol"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/66\/3\/562\/10641580\/biolreprod0562.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T22:15:07Z","timestamp":1706739307000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod66.3.562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3,1]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,3,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod66.3.562","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3,1]]}}}