{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:07:44Z","timestamp":1783555664112,"version":"3.55.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,12,1]]},"DOI":"10.1095\/biolreprod67.6.1756","type":"journal-article","created":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T14:20:04Z","timestamp":1132237204000},"page":"1756-1762","source":"Crossref","is-referenced-by-count":14,"title":["Regulation of Insulin-Like Growth Factor Binding Protein-6 Expression in the Reproductive Tract Throughout the Estrous Cycle and During the Development of the Placenta in the Ewe1"],"prefix":"10.1093","volume":"67","author":[{"given":"T.S.","family":"Gadd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.C.","family":"Osgerby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.C.","family":"Wathes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224155915_R1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/345078a0","article-title":"A growth deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting","volume":"345","year":"1990","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224155915_R2","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1210\/endo.138.3.4983","article-title":"Pregnancy-specific alterations in the expression of the insulin-like growth factor system during early placental development in the ewe","volume":"138","year":"1997","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224155915_R3","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.3168\/jds.S0022-0302(98)75747-9","article-title":"Role of the insulin Re growth factor (IGF) system in uterine function and placental development in ruminants","volume":"81","year":"1998","journal-title":"J Dairy Sci"},{"key":"key\n\t\t\t\t20170224155915_R4","first-page":"3","article-title":"Insulin-like growth factors and their binding proteins: biological actions","volume":"16","year":"1995","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t20170224155915_R5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1043-2760(97)00112-4","article-title":"Insulin-like growth factor-binding protein proteolysis: an emerging paradigm in insulin-like growth factor physiology","volume":"8","year":"1997","journal-title":"Trends Endocrinol Metab"},{"key":"key\n\t\t\t\t20170224155915_R6","doi-asserted-by":"crossref","first-page":"6572","DOI":"10.1021\/bi972894e","article-title":"Identification of O-glycosylation sites and partial characterization of carbohydrate structure and disulfide linkages of human insulin-like growth factor binding protein 6","volume":"37","year":"1998","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170224155915_R7","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1055\/s-2007-978723","article-title":"Insulin-like growth factor binding protein-6: the \u201cforgotten\u201d binding protein?","volume":"31","year":"1999","journal-title":"Horm Metab Res"},{"key":"key\n\t\t\t\t20170224155915_R8","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1530\/jrf.0.1050165","article-title":"Local action of trophoblast interferons in suppression of the development of oxytocin and oestradiol receptors in ovine endometrium","volume":"105","year":"1995","journal-title":"J Reprod Fertil"},{"key":"key\n\t\t\t\t20170224155915_R9","first-page":"1805","article-title":"Endothelial cells express insulin-like growth factor binding proteins 2 to 6","volume":"6","year":"1992","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t20170224155915_R10","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1095\/biolreprod51.2.296","article-title":"Insulin-like growth factor-binding proteins show distinct patterns of expression in the rat uterus","volume":"51","year":"1994","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224155915_R11","first-page":"1723","article-title":"Insulin-like growth factor system gene expression in human endometrium during the menstrual cycle","volume":"79","year":"1994","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224155915_R12","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1006\/dbio.1997.8533","article-title":"Insulin-like growth factor binding protein gene expression in the pregnant rat uterus and placenta","volume":"184","year":"1997","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20170224155915_R13","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1095\/biolreprod60.5.1172","article-title":"Tissue-specific expression of messenger ribonucleic acids for insulin-like growth factors and insulin-like growth factor binding proteins during perinatal development of the rat uterus","volume":"60","year":"1999","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224155915_R14","first-page":"2680","article-title":"The expression of insulin-like growth factor (IGF) and IGF binding protein (IGFBP) genes in human placenta and membranes: evidence for IGF-IGFBP interactions at the feto-maternal interface","volume":"81","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170224155915_R15","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0143-4004(96)90027-2","article-title":"The pattern of expression of insulin-like growth factor (IGF), IGF-I receptor and IGF binding protein (IGFBP) mRNAs in the rhesus monkey placenta suggests a paracrine mode of IGF-IGFBP interaction in placental development","volume":"17","year":"1996","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170224155915_R16","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1006\/bbrc.1993.1350","article-title":"Structural characterisation of the rat insulin-like growth factor binding protein-6 gene","volume":"191","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170224155915_R17","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1210\/endo.136.3.7532580","article-title":"Insulin-like growth factor binding protein-3 production by MCF-7 breast cancer cells: stimulation by retinoic acid and cyclic adenosine monophosphate and differential effects of estradiol","volume":"136","year":"1995","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224155915_R18","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1046\/j.1365-2265.1999.00694.x","article-title":"Circulating levels of human insulin-like growth factor binding protein-6 (IGFBP-6) in health and disease as determined by radioimmunoassay","volume":"50","year":"1999","journal-title":"Clin Endocrinol"},{"key":"key\n\t\t\t\t20170224155915_R19","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0167-4781(01)00192-0","article-title":"Structure and function of the human insulin-like growth factor binding protein (IGFBP)-6 promoter: identification of a functional retinoid response element","volume":"1518","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20170224155915_R20","first-page":"902","article-title":"Regulation of insulin-like growth factor (IGF)-binding protein-6 and mannose 6-phosphate\/IGF-II receptor expression in IGF-II overexpressing NW 3T3 cells","volume":"9","year":"1995","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t20170224155915_R21","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1677\/joe.0.1550225","article-title":"Regulation of IGF binding protein-6 by dexamethasone and IGFs in PC12 rat phaeochromocytoma cells","volume":"155","year":"1997","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20170224155915_R22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1677\/joe.0.1520221","article-title":"IGF-binding protein-6 is involved in growth inhibition in SH-SYSY human neuroblastoma cells: its production is both IGF- and cell density-dependent","volume":"152","year":"1997","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20170224155915_R23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1046\/j.1365-2265.1999.00833.x","article-title":"Hypoglycaemia associated with the production of insulin-like growth factor II and insulin-like growth factor binding protein 6 by a haemangiopericytoma","volume":"51","year":"1999","journal-title":"Clin Endocrinol"},{"key":"key\n\t\t\t\t20170224155915_R24","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1677\/joe.0.0490345","article-title":"Changes in ovarian secretion of oestradiol-17\u03b2 around oestrus in the sheep","volume":"49","year":"1971","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20170224155915_R25","first-page":"423","article-title":"Uterine blood flow during early pregnancy in ewes: interaction between the conceptus and the ovary bearing the corpus luteum","volume":"58","journal-title":"J Anim Sci 1984;"},{"key":"key\n\t\t\t\t20170224155915_R26","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1677\/joe.0.1380479","article-title":"Localization of oestradiol, progesterone and oxytocin receptors in the uterus during the oestrous cycle and early pregnancy of the ewe","volume":"138","year":"1993","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20170224155915_R27","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1677\/joe.0.1580173","article-title":"Regulation of oxytocin receptor in the placentome capsule throughout pregnancy in the ewe: the possible role of oestradiol receptor, progesterone receptor and aromatase","volume":"158","year":"1998","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20170224155915_R28","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1210\/endo.134.4.8137728","article-title":"Localization of insulin-like growth factor-I (IGF-I) and -II messenger ribonucleic acid and type 1 IGF receptors in the ovine uterus during the estrous cycle and early pregnancy","volume":"134","year":"1994","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224155915_R29","first-page":"432","article-title":"Interferons as hormones of pregnancy","volume":"13","year":"1992","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t20170224155915_R30","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1210\/endo.136.11.7588242","article-title":"Roles of insulin-like growth factor (IGF) receptors and IGF-binding proteins in IGF-II-induced proliferation and differentiation of L6A1 rat myoblasts","volume":"136","year":"1995","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224155915_R31","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1210\/endo.137.5.8612502","article-title":"Cortisol enhances the transcription of insulin-like growth factor binding protein-6 in cultured osteoblasts","volume":"137","year":"1996","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224155915_R32","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1006\/bbrc.1995.1962","article-title":"Effects of insulin-like growth factor (IGF) binding proteins (BPs) -3 and -6 on DNA synthesis of rat osteoblasts: further evidence for a role of auto-\/paracrine IGF I but not IGF II in stimulating osteoblast growth","volume":"212","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170224155915_R33","first-page":"1670","article-title":"Expression of insulin-like growth factor binding protein 6 complementary DNA alters neuroblastoma cell growth","volume":"58","year":"1998","journal-title":"Cancer Res"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/67\/6\/1756\/10557408\/biolreprod1756.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T03:41:35Z","timestamp":1554522095000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod67.6.1756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12,1]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,12,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod67.6.1756","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,12,1]]}}}