{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:28:55Z","timestamp":1779344935274,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1998,4,1]],"date-time":"1998-04-01T00:00:00Z","timestamp":891388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DU 229\/2\u20132"],"award-info":[{"award-number":["DU 229\/2\u20132"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[1998,4]]},"abstract":"<jats:p>\n                    A novel protein complex has been identified in human cells that has a molecular mass of approximately 450 kDa. It consists of at least eight different subunits including JAB1, the Jun activation\u2010domain binding protein 1, and Trip15, the thyroid hormone receptor\u2010interacting protein 15. The purified complex contains COP9 and COP11 protein homologs and is very similar, if not identical, to the plant COP9 complex involved in light\u2010mediated signal transduction. The isolated JAB1\u2010containing particle has kinase activity that phosphorylates I\u03baB\u03b1, the carboxy terminus of p105, and Ser\n                    <jats:sup>63<\/jats:sup>\n                    and\/or Ser\n                    <jats:sup>73<\/jats:sup>\n                    of the amino\u2010terminal activation domain of c\u2010Jun. The phosphorylation of c\u2010Jun requires the carboxy terminus of the protein containing the DNA binding and dimerization domains. Three subunits of the new complex\u2014Sgn3, Sgn5\/JAB1, and Sgn6\u2014exhibit sequence similarities to regulatory components of the 26S proteasome, which could indicate the existence of common substrate binding sites. Immunofluorescence staining reveals that the new complex shows a subcellular distribution similar to that of the 26S proteasome. The functional relationship of the two particles in regulating transcriptional activity is discussed. Considering the putative role of the complex in signal transduction and its widespread occurrence, we suggest the name JAB1\u2010containing signalosome.\u2014Seeger, M., Kraft, R., Ferrell, K., Bech\u2010Otschir, D., Dumdey, R., Schade, R., Gordon, C., Naumann, M., Dubiel, W. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.\n                    <jats:italic>FASEB J<\/jats:italic>\n                    . 12, 469\u2013478 (1998)\n                  <\/jats:p>","DOI":"10.1096\/fasebj.12.6.469","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T07:46:31Z","timestamp":1516261591000},"page":"469-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":298,"title":["A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits"],"prefix":"10.1096","volume":"12","author":[{"given":"Michael","family":"Seeger","sequence":"first","affiliation":[{"name":"Institute of Biochemistry Humboldt\u2010University Medical Faculty (Charit\u00e9)  Berlin 10117 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regine","family":"Kraft","sequence":"additional","affiliation":[{"name":"Max\u2010Delbr\u00fcck\u2010Center  Berlin 13122 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Ferrell","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry Humboldt\u2010University Medical Faculty (Charit\u00e9)  Berlin 10117 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawadschargal","family":"Bech\u2010Otschir","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry Humboldt\u2010University Medical Faculty (Charit\u00e9)  Berlin 10117 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renate","family":"Dumdey","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry Humboldt\u2010University Medical Faculty (Charit\u00e9)  Berlin 10117 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"Schade","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology Humboldt\u2010University Medical Faculty (Charit\u00e9)  Berlin 10117 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin","family":"Gordon","sequence":"additional","affiliation":[{"name":"MRC Human Genetics Unit Western General Hospital  Edinburgh EH4 2XU UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Naumann","sequence":"additional","affiliation":[{"name":"Max\u2010Planck\u2010Institut f\u00fcir Infektionsbiologie Abt. Molekulare Biologie  Berlin 10117 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Dubiel","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry Humboldt\u2010University Medical Faculty (Charit\u00e9)  Berlin 10117 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1998,4]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/374131a0"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(95)00151-5"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(09)00443-6"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.65.070196.004101"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00990967"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006837600040"},{"key":"e_1_2_3_8_1","doi-asserted-by":"crossref","first-page":"7059","DOI":"10.1016\/S0021-9258(17)37244-7","article-title":"A 26S protease subunit that binds ubiquitin\u2010conjugates.","volume":"269","author":"Deveraux Q.","year":"1994","journal-title":"J. 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