{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:55:33Z","timestamp":1790866533786,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1997,3,1]],"date-time":"1997-03-01T00:00:00Z","timestamp":857174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[1997,3]]},"abstract":"<jats:p>\n                    African trypanosomes are pathogens of humans and livestock in equatorial Africa. There is a great deal of resistance to present front line drugs for treating African trypanosomiasis such as melarsoprol (Arsobal) and pentamidine. In the search for new and novel drugs against this disease, we have found a unique transporter of S\u2010adenosylmethionine (AdoMet), a metabolite used in transmethylation reactions and polyamine synthesis. This transporter is distinct from those for methionine and adenosine, since AdoMet uptake was not inhibited by trypanocidal drugs, which compete with adenosine for transport. AdoMet analogs competing with [methyl\u2010\n                    <jats:sup>3<\/jats:sup>\n                    H]AdoMet for uptake required a positively charged sulfonium group on the 5' position of the ribose. Since transport of AdoMet does not normally occur to a significant extent in mammalian cells, the parasite transporter provides a selective and novel route to deliver new chemotherapeutic agents against these organisms. Goldberg, B., Yarlett, N., Sufrin, J., Lloyd, D., Bacchi, C. J. A unique transporter of S\u2010adenosylmethionine in African trypanosomes.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    11, 256\u2010260 (1997)\n                  <\/jats:p>","DOI":"10.1096\/fasebj.11.4.9068614","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T06:02:54Z","timestamp":1516255374000},"page":"256-260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["A unique transporter of S\u2010adenosylmethionine in African trypanosomes"],"prefix":"10.1096","volume":"11","author":[{"given":"Burt","family":"Goldberg","sequence":"first","affiliation":[{"name":"Haskins Laboratories Pace Univesity New York New York 10038 USA"},{"name":"Department of Chemistry and Physical Sciences Pace Univesity New York New York 10038 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Yarlett","sequence":"additional","affiliation":[{"name":"Haskins Laboratories Pace Univesity New York New York 10038 USA"},{"name":"Department of Biology Pace Univesity New York New York 10038 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Sufrin","sequence":"additional","affiliation":[{"name":"University of Wales Cardiff CF1 3TL Wales U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Physical Sciences Pace Univesity New York New York 10038 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus J.","family":"Bacchi","sequence":"additional","affiliation":[{"name":"Haskins Laboratories Pace Univesity New York New York 10038 USA"},{"name":"Grace Cancer Drug Center Roswell Park Cancer Institute Buffalo New York 14263 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1997,3]]},"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fasebj.11.4.9068614","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fasebj.11.4.9068614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:07:00Z","timestamp":1761674820000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fasebj.11.4.9068614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,3]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,3]]}},"alternative-id":["10.1096\/fasebj.11.4.9068614"],"URL":"https:\/\/doi.org\/10.1096\/fasebj.11.4.9068614","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,3]]},"assertion":[{"value":"1996-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-03-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}