{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T01:57:43Z","timestamp":1770515863737,"version":"3.49.0"},"reference-count":52,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[1999,11,1]],"date-time":"1999-11-01T00:00:00Z","timestamp":941414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[1999,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Peroxynitrite, a potent cytotoxic oxidant formed by the reaction of nitric oxide (NO) with the superoxide anion, was recently proposed to play a major pathogenic role in the inflammatory process. Here we have investigated the effects of endogenous melatonin, a known scavenger of peroxynitrite, in rats subjected to carrageenan\u2010induced pleurisy. Endogenous melatonin was depleted in rats maintained on 24 h light cycle for 1 wk.\n                    <jats:italic>In vivo<\/jats:italic>\n                    depletion of endogenous melatonin enhanced the carrageenan\u2010induced degree of pleural exudation and polymorphonuclear leukocyte migration in rats subjected to carrageenan\u2010induced pleurisy. Lung myeloperoxidase activity and lipid peroxidation were significantly increased in melatonin\u2010deprived rats. However, the inducible NO synthase in lung samples was unaffected by melatonin depletion. Immunohistochemical analysis for nitrotyrosine revealed a positive staining in lungs from carrageenan\u2010treated rats that was markedly enhanced in melatonin\u2010deprived rats. Furthermore, melatonin depletion significantly increased peroxynitrite formation as measured by the oxidation of the fluorescent dye dihydrorhoda\u2010mine 123, enhanced DNA damage and the decrease in mitochondrial respiration and reduced the cellular levels of NAD+ in macrophages harvested from the pleural cavity of rats subjected to carrageenan\u2010induced pleurisy.\n                    <jats:italic>In vivo<\/jats:italic>\n                    treatment with exogenous melatonin (15 mg\/kg intraperitoneal) significantly reversed the effects of melatonin depletion. Thus, endogenous melatonin plays an important protective role against carrageenan\u2010induced local inflammation.\u2014 Cuzzocrea, S., Tan, D.\u2010X., Costantino, G., Mazzon, E., Caputi, A. P., Reiter, R. J. The protective role of endogenous melatonin in carrageenan\u2010induced pleurisy in the rat.\n                    <jats:italic>FASEB J<\/jats:italic>\n                    . 13, 1930\u20131938 (1999)\n                  <\/jats:p>","DOI":"10.1096\/fasebj.13.14.1930","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T04:39:04Z","timestamp":1516855144000},"page":"1930-1938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["The protective role of endogenous melatonin in carrageenan\u2010induced pleurisy in the rat"],"prefix":"10.1096","volume":"13","author":[{"given":"Salvatore","family":"Cuzzocrea","sequence":"first","affiliation":[{"name":"Institute of Pharmacology University of Messina  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dun\u2010Xian","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Cellular and Structural Biology The University of Texas Health Center at San Antonio  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina","family":"Costantino","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology University of Messina  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Mazzon","sequence":"additional","affiliation":[{"name":"Biomorphology School of Medicine University of Messina  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achille P.","family":"Caputi","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology University of Messina  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russel J.","family":"Reiter","sequence":"additional","affiliation":[{"name":"Department of Cellular and Structural Biology The University of Texas Health Center at San Antonio  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1999,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-6997(25)06663-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.6.12.1381691"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(97)00280-3"},{"key":"e_1_2_6_5_1","first-page":"245","article-title":"Use of antioxidant therapy in shock, and trauma","volume":"35","author":"Youn Y. 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