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We compared the postinjury activities of thrombin and gelatinases, two types of proteolytic activities known to be critically involved in tissue healing, in nonregenerative (rat optic nerve) and regenerative (fish optic nerve and rat sciatic nerve) neural tissue. Unlike gelatinases, whose induction pattern was comparable in all three nerves, thrombin\u2010like activity differed clearly between regenerating and nonregenerating nervous systems. Postinjury levels of this latter activity seem to dictate whether it will display beneficial or detrimental effects on the capacity of the tissue for repair. The results of this study further highlight the fact that tissue repair and nerve regeneration are closely linked and that substances that are not unique to the nervous system, but participate in wound healing in general, are also crucial for regeneration or its failure in the nervous system.\u2014Friedmann, I., Faber\u2010Elman, A., Yoles, E., Schwartz, M. Injury\u2010induced gelatinase and thrombin\u2010like activities in regenerating and nonregenerating nervous systems.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    13, 533\u2013543 (1999)\n                  <\/jats:p>","DOI":"10.1096\/fasebj.13.3.533","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T07:34:17Z","timestamp":1516260857000},"page":"533-543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Injury\u2010induced gelatinase and thrombin\u2010like activities in regenerating and nonregenerating nervous systems"],"prefix":"10.1096","volume":"13","author":[{"given":"Igor","family":"Friedmann","sequence":"first","affiliation":[{"name":"Department of Neurobiology The Weizmann Institute of Science  76100 Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Faber-Elman","sequence":"additional","affiliation":[{"name":"Department of Neurobiology The Weizmann Institute of Science  76100 Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eti","family":"Yoles","sequence":"additional","affiliation":[{"name":"Department of Neurobiology The Weizmann Institute of Science  76100 Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Neurobiology The Weizmann Institute of Science  76100 Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1999,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.8.13.7926367"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90289-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/284264a0"},{"key":"e_1_2_7_5_1","first-page":"1524","article-title":"Components of the plasminogen activator system in astrocytes are modulated by tumor necrosis factor-alpha and interleukin-1 beta through similar signal transduction pathways","volume":"65","author":"Faber Elman A.","year":"1995","journal-title":"J. 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