{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:24:31Z","timestamp":1778804671973,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1990,2,1]],"date-time":"1990-02-01T00:00:00Z","timestamp":633830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[1990,2]]},"abstract":"<jats:p>\n                    Transforming growth factor \u03b2 (TGF\u03b2) has been implicated as having a central role in the postinflammatory tissue regeneration and fibrosis. To test its potential involvement in events that follow hepatotoxin\u2010mediated liver regeneration and fibrosis, we quantitated changes in the steady\u2010state levels of TGF\u03b2 mRNA in parenchymal and nonparenchymal cells at various times after an acute treatment with CCl\n                    <jats:sub>4<\/jats:sub>\n                    , and also compared TGF\u03b2 gene expression in these two cell types from livers subjected to chronic CCl\n                    <jats:sub>4<\/jats:sub>\n                    treatment. The parenchymal and nonparenchymal cells from normal liver contained undetectable amounts of TGF\u03b2 mRNA. In contrast, we could readily detect TGF\u03b2 specific transcripts in both the parenchymal and nonparenchymal cells after acute injury. Nonparenchymal cells from acutely injured liver contained fivefold greater amounts of TGF\u03b2 mRNA, which peaked at 48 h and declined thereafter. In chronically treated rat livers (1, 2, 3, and 7 wk after the initiation of CCl\n                    <jats:sub>4<\/jats:sub>\n                    treatment), increased expression of TGF\u03b2 mRNA was found only in nonparenchymal cells obtained after 2\u20103 wk of treatment. Strikingly large elevations in the steady\u2010state levels of \u03b2\u2010actin mRNA in CCl\n                    <jats:sub>4<\/jats:sub>\n                    \u2010treated liver were also observed, which may be related to the known regenerative processes associated with acute liver toxicity. Changing dynamics of TGF\u03b2 gene expression, therefore, appear to be an important attribute of regenerating liver after acute or chronic CCl\n                    <jats:sub>4<\/jats:sub>\n                    toxicity.\u2014 A\n                    <jats:sc>rmendariz<\/jats:sc>\n                    \u2010B\n                    <jats:sc>orunda<\/jats:sc>\n                    , J.; S\n                    <jats:sc>eyer<\/jats:sc>\n                    , J. M.; K\n                    <jats:sc>ang<\/jats:sc>\n                    , A. H.; R\n                    <jats:sc>aghow<\/jats:sc>\n                    , R. Regulation of TGF\u03b2 gene expression in rat liver intoxicated with carbon tetrachloride.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    4: 215\u2010221; 1990.\n                  <\/jats:p>","DOI":"10.1096\/fasebj.4.2.2298342","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T07:53:50Z","timestamp":1516262030000},"page":"215-221","source":"Crossref","is-referenced-by-count":110,"title":["Regulation of TGF\u03b2 gene expression in rat liver intoxicated with carbon tetrachloride"],"prefix":"10.1096","volume":"4","author":[{"given":"Juan","family":"Armendariz\u2010Borunda","sequence":"first","affiliation":[{"name":"Veterans Administration Medical Center and Departments of Biochemistry, Pharmacology, and Medicine University of Tennessee Memphis Tennessee 38104 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome M.","family":"Seyer","sequence":"additional","affiliation":[{"name":"Veterans Administration Medical Center and Departments of Biochemistry, Pharmacology, and Medicine University of Tennessee Memphis Tennessee 38104 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew H.","family":"Kang","sequence":"additional","affiliation":[{"name":"Veterans Administration Medical Center and Departments of Biochemistry, Pharmacology, and Medicine University of Tennessee Memphis Tennessee 38104 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajendra","family":"Raghow","sequence":"additional","affiliation":[{"name":"Veterans Administration Medical Center and Departments of Biochemistry, Pharmacology, and Medicine University of Tennessee Memphis Tennessee 38104 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1990,2]]},"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fasebj.4.2.2298342","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fasebj.4.2.2298342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T19:51:51Z","timestamp":1761681111000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fasebj.4.2.2298342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,2]]}},"alternative-id":["10.1096\/fasebj.4.2.2298342"],"URL":"https:\/\/doi.org\/10.1096\/fasebj.4.2.2298342","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,2]]}}}