{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:40:03Z","timestamp":1770972003668,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1992,1,6]],"date-time":"1992-01-06T00:00:00Z","timestamp":694656000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:p>\n                    The filling state of the intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    stores of rat thymocytes regulates plasma membrane permeability to Mn\n                    <jats:sup>2+<\/jats:sup>\n                    , used here as a Ca\n                    <jats:sup>2+<\/jats:sup>\n                    surrogate for plasma membrane Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels. Emptying of the Ca\n                    <jats:sup>2+<\/jats:sup>\n                    stores accelerated Mn\n                    <jats:sup>2+<\/jats:sup>\n                    entry about 10\u2010fold, and refilling with Ca\n                    <jats:sup>2+<\/jats:sup>\n                    restored low Mn\n                    <jats:sup>2+<\/jats:sup>\n                    permeability. The acceleration of Mn\n                    <jats:sup>2+<\/jats:sup>\n                    entry observed in cells with empty intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    stores was prevented by cytochrome P450 inhibitors. Imidazole antimycotics, especially econazole and miconazole, were the most potent inhibitors (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u224c 10\n                    <jats:sup>\u20136<\/jats:sup>\n                    <jats:sc>m<\/jats:sc>\n                    ). The inhibitor sensitivity profile was similar to IA\u2010type cytochrome P450. Calmodulin antagonists increased the plasma membrane permeability to Mn\n                    <jats:sup>2+<\/jats:sup>\n                    in cells with filled Ca\n                    <jats:sup>2+<\/jats:sup>\n                    stores, and this effect was also blocked by imidazole antimycotics. On this basis, we propose a model in which activation of a cytochrome P450, situated at the Ca\n                    <jats:sup>2+<\/jats:sup>\n                    stores, opens a plasma membrane Ca\n                    <jats:sup>2+<\/jats:sup>\n                    pathway. This activity would be inhibited by Ca\n                    <jats:sup>2+<\/jats:sup>\n                    inside the stores by a calmodulin\u2010dependent mechanism.\u2014Alvarez, J.; Montero, M.; Garcia\u2010Sancho, J. Cytochrome P450 may regulate plasma membrane Ca\n                    <jats:sup>2+<\/jats:sup>\n                    permeability according to the filling state of the intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    stores.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    6: 786\u2010792; 1992.\n                  <\/jats:p>","DOI":"10.1096\/fasebj.6.2.1537469","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T08:40:14Z","timestamp":1516264814000},"page":"786-792","source":"Crossref","is-referenced-by-count":93,"title":["Cytochrome P450 may regulate plasma membrane Ca\n                    <sup>2+<\/sup>\n                    permeability according to the filling state of the intracellular Ca\n                    <sup>2+<\/sup>\n                    stores"],"prefix":"10.1096","volume":"6","author":[{"given":"Javier","family":"Alvarez","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Fisiolog\u00eda Facultad de Medicina Universidad de Valladolid Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayte","family":"Montero","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Fisiolog\u00eda Facultad de Medicina Universidad de Valladolid Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Garcia\u2010Sancho","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Fisiolog\u00eda Facultad de Medicina Universidad de Valladolid Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1992,1,6]]},"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fasebj.6.2.1537469","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fasebj.6.2.1537469","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:26:56Z","timestamp":1761665216000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fasebj.6.2.1537469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1096\/fasebj.6.2.1537469"],"URL":"https:\/\/doi.org\/10.1096\/fasebj.6.2.1537469","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}