{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T23:47:09Z","timestamp":1770767229280,"version":"3.50.0"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1992,2,1]],"date-time":"1992-02-01T00:00:00Z","timestamp":696902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002570","name":"American Association of Immunologists","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002570","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005804","name":"Federation of American Societies for Experimental Biology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[1992,2]]},"abstract":"<jats:p>\n                    Many mechanisms may account for immune\u2010mediated pathology after viral infections. Although several means have been hypothesized to play a role in disease, a widely accepted mechanism for viral\u2010induced autoimmunity is molecular mimicry. It is thought that damage could result from an immune response to similar regions shared between virus and the host. Using computer\u2010aided analysis, many sequence homologies have been identified between virus and host antigens. Using peptides corresponding to these regions, immunologic cross\u2010reactivity has been found. In some cases, monoclonal antibodies to peptides of these regions have been shown to directly induce or augment disease in animal models. Using this approach to identify similar regions, it is possible to associate a known autoantigen with an infectious agent in autoimmune diseases in which there is no known etiologic agent. Conversely, it would also be possible to associate a known viral constituent with an unknown host antigen. Furthermore, identification of disease\u2010inducing regions of autoantigens or viral proteins may lead to immunotherapeutic approaches to establish tolerance or anergy to such disease\u2010inducing regions.\u2014Barnett, L. A. Fujinami, R. S. Molecular mimicry: a mechanism for autoimmune injury.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    6: 840\u2010844; 1992.\n                  <\/jats:p>","DOI":"10.1096\/fasebj.6.3.1740233","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T05:17:16Z","timestamp":1516857436000},"page":"840-844","source":"Crossref","is-referenced-by-count":74,"title":["Molecular mimicry: a mechanism for autoimmune injury\n                    <sup>1<\/sup>"],"prefix":"10.1096","volume":"6","author":[{"given":"Lou Ann","family":"Barnett","sequence":"first","affiliation":[{"name":"Department of Neurology University of Utah Salt Lake City Utah 84132 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Fujinami","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah Salt Lake City Utah 84132 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1992,2]]},"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fasebj.6.3.1740233","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fasebj.6.3.1740233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:16:22Z","timestamp":1761668182000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fasebj.6.3.1740233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,2]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,2]]}},"alternative-id":["10.1096\/fasebj.6.3.1740233"],"URL":"https:\/\/doi.org\/10.1096\/fasebj.6.3.1740233","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,2]]}}}