{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:25:20Z","timestamp":1790983520181,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1993,2,1]],"date-time":"1993-02-01T00:00:00Z","timestamp":728524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[1993,2]]},"abstract":"<jats:p>\n                    With the recent discoveries of novel forms of phospholipases A\n                    <jats:sub>2<\/jats:sub>\n                    (PLA\n                    <jats:sub>2S<\/jats:sub>\n                    ),\n                    <jats:sup>2<\/jats:sup>\n                    new schemes for the roles of various PLA\n                    <jats:sub>2S<\/jats:sub>\n                    in lipid metabolism must be considered. The type II 14\u2010kDa PLA\n                    <jats:sub>2<\/jats:sub>\n                    isolated from human synovial fluid or platelet has many of the biochemical characteristics of the homologous snake venom and mammalian pancreatic PLA\n                    <jats:sub>2S<\/jats:sub>\n                    , It appears to function both as a cell\u2010associated enzyme and extracellularly, where its expression and\/or release is regulated by a variety of mediators such as cytokines or growth factors. The mammalian 85\u2010kDa PLA\n                    <jats:sub>2<\/jats:sub>\n                    purified from monocytic cells or platelets has no sequence homology to the 14\u2010kDa PLA\n                    <jats:sub>2<\/jats:sub>\n                    and exhibits biochemically different characteristics. It translocates from cytosol to particulate cell fractions in the presence of submicromolar levels of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    and has a substrate preference for\n                    <jats:italic>sn<\/jats:italic>\n                    \u20102\u2010arachidonoyl\u2013ontaining phospholipids. The cellular function and relative importance of these two enzymes in lipid metabolism remain to be determined. In this review, the biochemistry, localization, function, and regulation of these two distinct mammalian Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010de pendent PLA\n                    <jats:sub>2<\/jats:sub>\n                    are compared.\u2014\u2010Mayer, R. J.; Marshall, L. A. New insights on mammalian phospholipase A\n                    <jats:sub>2<\/jats:sub>\n                    (s); comparison of arachidonoyl\u2010selective and \u2010nonselective enzymes.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    7: 339\u2010348; 1993.\n                  <\/jats:p>","DOI":"10.1096\/fasebj.7.2.8440410","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T06:27:32Z","timestamp":1516861652000},"page":"339-348","source":"Crossref","is-referenced-by-count":343,"title":["New insights on mammalian phospholipase A\n                    <sub>2<\/sub>\n                    (s); comparison of arachidonoyl\u2010selective and \u2010nonselective enzymes"],"prefix":"10.1096","volume":"7","author":[{"given":"Ruth J.","family":"Mayer","sequence":"first","affiliation":[{"name":"Medicinal Chemistry Smith Kline Beccham Pharmaceuticals King of Prussia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Smith Kline Beccham Pharmaceuticals King of Prussia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1993,2]]},"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fasebj.7.2.8440410","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fasebj.7.2.8440410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:42:27Z","timestamp":1761691347000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fasebj.7.2.8440410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,2]]}},"alternative-id":["10.1096\/fasebj.7.2.8440410"],"URL":"https:\/\/doi.org\/10.1096\/fasebj.7.2.8440410","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,2]]}}}