{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:46:19Z","timestamp":1788176779822,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["S\u201087002\u201009\u201001"],"award-info":[{"award-number":["S\u201087002\u201009\u201001"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["CRSII3_160717\/1"],"award-info":[{"award-number":["CRSII3_160717\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FASEB BioAdvances"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The ability of the liver to restore its original volume following tissue loss has been associated with the Hippo\u2010YAP1 pathway, a key controller of organ size. Yes\u2010associated protein 1 (YAP1)\u2014a growth effector usually restrained by Hippo signaling\u2014is believed to be of particular importance; however, its role in liver regeneration remains ill\u2010defined. To explore its function, we knocked down YAP1 prior to standard 70%\u2010hepatectomy (sHx) using a hepatocyte\u2010specific nanoformulation. Knockdown was effective during the major parenchymal growth phase (S\u2010phase\/M\u2010phase peaks at 32\u00a0hours\/48\u00a0hours post\u2010sHx). Liver weight gain was completely suppressed by the knockdown at 32\u00a0hours, but was reaccelerated toward 48\u00a0hours. Likewise, proliferative markers,\n                    <jats:italic>Ccna2\/b2<\/jats:italic>\n                    and YAP1 target gene expression were downregulated at 32\u00a0hours, but re\u2010elevated at 48\u00a0hours post\u2010sHx. Nonetheless, knockdown slightly compromised survival after sHx. When assessing a model of resection\u2010induced liver failure (extended 86%\u2010hepatectomy, eHx) featuring deficient S\u2010 and M\u2010phase progression, YAP1 was not induced at 32\u00a0hours, but upregulated at 48\u00a0hours post\u2010eHx, confirming its dissociation from M\u2010phase regulation. Therefore, YAP1 is vital to push hepatocytes into cycle and through the S\u2010phase, but is not required for further cell cycle progression during liver regeneration. The examination of YAP1 in human livers suggested its function is conserved in the regenerating mammalian liver.\n                  <\/jats:p>","DOI":"10.1096\/fba.1023","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T10:59:24Z","timestamp":1553511564000},"page":"51-61","source":"Crossref","is-referenced-by-count":21,"title":["Yes\u2010associated protein promotes early hepatocyte cell cycle progression in regenerating liver after tissue loss"],"prefix":"10.1096","volume":"1","author":[{"given":"Christoph","family":"Tschuor","sequence":"first","affiliation":[{"name":"Laboratory of the Swiss HPB and Transplantation Center, Department of Surgery University Hospital Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Kachaylo","sequence":"additional","affiliation":[{"name":"Laboratory of the Swiss HPB and Transplantation Center, Department of Surgery University Hospital Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Ungeth\u00fcm","sequence":"additional","affiliation":[{"name":"Laboratory of the Swiss HPB and Transplantation Center, Department of Surgery University Hospital Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuolun","family":"Song","sequence":"additional","affiliation":[{"name":"Laboratory of the Swiss HPB and Transplantation Center, Department of Surgery University Hospital Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuno","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Laboratory of the Swiss HPB and Transplantation Center, Department of Surgery University Hospital Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"S\u00e1nchez\u2010Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Laboratory of the Swiss HPB and Transplantation Center, Department of Surgery University Hospital Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Linecker","sequence":"additional","affiliation":[{"name":"Laboratory of the Swiss HPB and Transplantation Center, Department of Surgery University Hospital Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patryk","family":"Kambakamba","sequence":"additional","affiliation":[{"name":"Laboratory of the Swiss HPB and Transplantation Center, Department of Surgery University Hospital Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri A.","family":"Raptis","sequence":"additional","affiliation":[{"name":"Laboratory of the Swiss HPB and Transplantation Center, Department of Surgery University Hospital Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00ebrparim","family":"Limani","sequence":"additional","affiliation":[{"name":"Laboratory of the Swiss HPB and Transplantation Center, Department of Surgery University Hospital Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilmurodjon","family":"Eshmuminov","sequence":"additional","affiliation":[{"name":"Laboratory of the Swiss HPB and Transplantation Center, Department of Surgery University Hospital Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Graf","sequence":"additional","affiliation":[{"name":"Laboratory of the Swiss HPB and Transplantation Center, Department of Surgery University Hospital Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amedeo","family":"Columbano","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Cagliari Sardinia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bostjan","family":"Humar","sequence":"additional","affiliation":[{"name":"Laboratory of the Swiss HPB and Transplantation Center, Department of Surgery University Hospital Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Alain","family":"Clavien","sequence":"additional","affiliation":[{"name":"Laboratory of the Swiss HPB and Transplantation Center, Department of Surgery University Hospital Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.08.045"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.08.043"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.02.040"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra065156"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.10.047"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.10.039"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25769"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00077.2014"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201506089"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28542"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.008"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.205"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.262816.115"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000189131.90876.9e"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28809"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29226"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23138"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa4559"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E15-08-0598"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117522"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.02.027"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1499-3872(12)60161-1"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13014"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035754"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.02.019"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090675"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201797609"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29663"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-17-0382"}],"container-title":["FASEB BioAdvances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1096%2Ffba.1023","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fba.1023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:30:34Z","timestamp":1761690634000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fba.1023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,27]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1096\/fba.1023"],"URL":"https:\/\/doi.org\/10.1096\/fba.1023","archive":["Portico"],"relation":{},"ISSN":["2573-9832","2573-9832"],"issn-type":[{"value":"2573-9832","type":"print"},{"value":"2573-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,27]]}}}