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Recent evidence suggests that alarmins\/DAMPs may also trigger tissue regeneration and repair, suggesting a potential contribution to tissue fibrogenesis. High mobility group B1 (HMGB1), a bona fide alarmin\/DAMP, may be released passively by necrotic cells or actively secreted by innate immune cells. Macrophages can release large amounts of HMGB1 and play a key role in wound healing and regeneration processes. Here, we hypothesized that macrophages may be a key source of HMGB1 and thereby contribute to wound healing and fibrogenesis. Surprisingly, cell\u2010specific deletion approaches, demonstrated that macrophage\u2010derived HMGB1 is not involved in tissue fibrogenesis in multiple organs with different underlying pathologies. Compared to control HMGB1\n                    <jats:sup>Flox<\/jats:sup>\n                    mice, mice with macrophage\u2010specific HMGB1 deletion (HMGB1\n                    <jats:sup>\u0394Mac<\/jats:sup>\n                    ) do not display any modification of fibrogenesis in the liver after CCL\n                    <jats:sub>4<\/jats:sub>\n                    or thioacetamide treatment and bile duct ligation; in the kidney following unilateral ureter obstruction; and in the heart after transverse aortic constriction. Of note, even under thermoneutral housing, known to exacerbate inflammation and fibrosis features, HMGB1\n                    <jats:sup>\u0394Mac<\/jats:sup>\n                    mice do not show impairment of fibrogenesis. In conclusion, our study clearly establishes that macrophage\u2010derived HMGB1 does not contribute to tissue repair and fibrogenesis.\n                  <\/jats:p>","DOI":"10.1096\/fba.2018-00035","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T10:55:01Z","timestamp":1553511301000},"page":"227-245","source":"Crossref","is-referenced-by-count":9,"title":["Macrophage\u2010derived HMGB1 is dispensable for tissue fibrogenesis"],"prefix":"10.1096","volume":"1","author":[{"given":"Jean","family":"Personnaz","sequence":"first","affiliation":[{"name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires, UMR 1048\/I2MC, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Universit\u00e9 de Toulouse Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enzo","family":"Piccolo","sequence":"additional","affiliation":[{"name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires, UMR 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