{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:35:59Z","timestamp":1787009759109,"version":"build-2736575974"},"reference-count":81,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FASEB BioAdvances"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A variety of internal and external factors such as exercise, nutrition, inflammation, and cancer\u2010associated cachexia affect the regulation of skeletal muscle mass. Because skeletal muscle functions as a crucial regulator of whole body metabolism, rather than just as a motor for locomotion, the enhancement and maintenance of muscle mass and function are required to maintain health and reduce the morbidity and mortality associated with diseases involving muscle wasting. Recent studies in this field have made tremendous progress; therefore, identification of the mechanisms that regulate skeletal muscle mass is necessary for the physical and nutritional management of both athletes and patients with muscle wasting disease. In this review, we present an overall picture of the interactions regulating skeletal muscle mass, particularly focusing on the insulin\u2010like growth factor\u2010I (IGF\u2010I)\/insulin\u2010Akt\u2010mammalian target of rapamycin (mTOR) pathway, skeletal muscle inactivity, and endurance and resistance exercise. We also discuss the contribution of nitric oxide (NO) to the regulation of skeletal muscle mass based on the current knowledge of the novel role of NO in these processes.<\/jats:p>","DOI":"10.1096\/fba.2018-00080","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T10:56:36Z","timestamp":1553511396000},"page":"364-374","source":"Crossref","is-referenced-by-count":31,"title":["Molecular regulation of skeletal muscle mass and the contribution of nitric oxide: A review"],"prefix":"10.1096","volume":"1","author":[{"given":"Jun","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical Science Josai University Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical 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