{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:17:37Z","timestamp":1762161457037,"version":"build-2065373602"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18H02321"],"award-info":[{"award-number":["18H02321"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FASEB BioAdvances"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Oocyte spindle transfer (OST) is a potent reproductive technology used for mammals that enables the spindle in a deteriorated oocyte at the metaphase of the second meiotic division (MII) to serve as the genetic material for producing descendants. However, whether postnatal growth is achieved via OST using developmentally deteriorated MII oocytes remains unclear. At 16\u00a0h after human chorionic gonadotropin administration, denuded MII oocytes immediately after retrieval from oviducts (0\u00a0h\u2010oocytes) were used for in vitro fertilization (IVF) as controls. For IVF using postovulatory\u2010aged oocytes, the 0\u00a0h\u2010oocytes were further incubated for 12\u00a0h and 24\u00a0h (12\u00a0h\u2010 and 24\u00a0h\u2010oocytes). These mouse oocytes served as a model for assessing the postnatal growth of individuals produced via OST from developmentally deteriorated oocytes. The embryos from 12\u00a0h\u2010 and 24\u00a0h\u2010oocyte spindles exhibited high rates of development up to the neonatal stage as good as the non\u2010manipulated controls. However, the mice derived from the 24\u00a0h\u2010oocyte spindles displayed heavier body weights and greater feed consumption than both controls and mice derived from 12\u00a0h\u2010oocyte spindles. Our results demonstrate the feasibility of OST as a potent reproductive technology and its limitation in the use of excessively aged postovulatory oocytes in mammalian reproduction.<\/jats:p>","DOI":"10.1096\/fba.2019-00005","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T19:29:34Z","timestamp":1553628574000},"page":"393-403","source":"Crossref","is-referenced-by-count":6,"title":["Overgrowth of mice generated from postovulatory\u2010aged oocyte spindles"],"prefix":"10.1096","volume":"1","author":[{"given":"Kouki","family":"Shiina","sequence":"first","affiliation":[{"name":"Laboratory of Animal Genetics and Reproduction, Research Faculty of Agriculture Hokkaido University Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Genetics and Reproduction, Research Faculty of Agriculture Hokkaido University Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumi","family":"Yokoi","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Genetics and Reproduction, Research Faculty of Agriculture Hokkaido University Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanako","family":"Bai","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Genetics and Reproduction, Research Faculty of Agriculture Hokkaido University Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Genetics and Reproduction, Research Faculty of Agriculture Hokkaido University Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Kawahara","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Genetics and Reproduction, Research Faculty of Agriculture Hokkaido University Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/385810a0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02402"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.116.141309"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2010.11.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(01)00466-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.09.022"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.03.105"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod66.2.495"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.20538"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-008-9282-6"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2017.01.020"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20592"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.01.013"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.2.429"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a019080"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1530\/ror.0.0040125"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.111.095711"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2011.04.017"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0660161"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1331"},{"key":"e_1_2_9_22_1","first-page":"7","article-title":"Culture of mouse ova","volume":"14","author":"Whittingham DG","year":"1971","journal-title":"J Reprod Fertil Suppl"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(88)90425-3"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.004291"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep14512"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)48918-1"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.744144"},{"volume-title":"Reproduction in Farm Animals","year":"1993","author":"Hafez E","key":"e_1_2_9_28_1"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-17-0372"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-015-0033-y"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2014.11.029"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddiscovery.2016.9"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1152"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002709"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-2098"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1262\/jrd.10-145A"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1262\/jrd.18114"}],"container-title":["FASEB BioAdvances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fba.2019-00005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fba.2019-00005","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fba.2019-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T21:06:34Z","timestamp":1761685594000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fba.2019-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,15]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1096\/fba.2019-00005"],"URL":"https:\/\/doi.org\/10.1096\/fba.2019-00005","archive":["Portico"],"relation":{},"ISSN":["2573-9832","2573-9832"],"issn-type":[{"type":"print","value":"2573-9832"},{"type":"electronic","value":"2573-9832"}],"subject":[],"published":{"date-parts":[[2019,4,15]]}}}