{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:35:53Z","timestamp":1787009753379,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009809","name":"John T. Reid Charitable Trusts","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FASEB BioAdvances"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Malignant mesothelioma (MM) is an almost invariably fatal cancer caused by asbestos exposure. The toxicity of asbestos fibers is related to their physicochemical properties and the generation of free radicals. We set up a pilot study to investigate the potential of the zeolite clinoptilolite to counteract the asbestos carcinogenesis by preventing the generation of reactive nitrogen and oxygen radicals. In cell culture experiments, clinoptilolite prevented asbestos\u2010induced cell death, reactive oxygen species production, DNA degradation, and overexpression of genes known to be up\u2010regulated by asbestos. In an asbestos\u2010induced transgenic mouse model of MM, mice were injected intraperitoneal injections with blue asbestos, with or without clinoptilolite, and monitored for 30\u00a0weeks. By the end of the trial all 13 mice injected with asbestos alone had reached humane end points, whereas only 7 of 29 mice receiving crocidolite and clinoptilolite reached a similar stage of disease. Post\u2010mortem examination revealed pinpoint mesothelioma\u2010like tumors in affected mice, and the absence of tumor formation in surviving mice. Interestingly, the macrophage clearance system, which was largely suppressed in asbestos\u2010treated mice, exhibited evidence of increased phagocytosis in mice treated with asbestos and clinoptilolite. Our study suggests that inhibiting the asbestos\u2010induced generation of reactive oxygen species and stimulating the macrophage system may represent a pathway to amelioration of asbestos\u2010induced toxicity. Additional studies are warranted to explore the underlying mechanisms responsible for our observations.<\/jats:p>","DOI":"10.1096\/fba.2019-00040","type":"journal-article","created":{"date-parts":[[2019,7,27]],"date-time":"2019-07-27T08:29:53Z","timestamp":1564216193000},"page":"550-560","source":"Crossref","is-referenced-by-count":5,"title":["Zeolites ameliorate asbestos toxicity in a transgenic model of malignant mesothelioma"],"prefix":"10.1096","volume":"1","author":[{"given":"Xiyong","family":"Fan","sequence":"first","affiliation":[{"name":"School of Life Sciences University of Technology Sydney Broadway NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"School of Life Sciences University of Technology Sydney Broadway NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleo","family":"Robinson","sequence":"additional","affiliation":[{"name":"School of 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