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Unexpectedly, 4\u00a0weeks after performing in the\n                    <jats:italic>SocioBox,<\/jats:italic>\n                    mice displayed robust social avoidance during Y\u2010maze sociability testing. This unique \u201csociophobia\u201d acquisition could be documented in independent cohorts. We therefore employed infrared thermography as a non\u2010invasive method of stress\u2010monitoring during\n                    <jats:italic>SocioBox<\/jats:italic>\n                    testing (presentation of five other mice) versus empty box. A higher\n                    <jats:italic>Centralization Index<\/jats:italic>\n                    (body\/tail temperature) in the\n                    <jats:italic>SocioBox<\/jats:italic>\n                    correlated negatively with social recognition memory and, after 4\u00a0weeks, with social preference in the Y\u2010maze. Assuming that social stimuli might be associated with characteristic thermo\u2010responses, we exposed healthy men (N\u00a0=\u00a0103) with a comparably high intelligence level to a standardized test session including two cognitive tests with or without social component (face versus pattern recognition). In some analogy to the\n                    <jats:italic>Centralization Index<\/jats:italic>\n                    (within\u2010subject measure) used in mice, the\n                    <jats:italic>Reference Index<\/jats:italic>\n                    (ratio nose\/malar cheek temperature) was introduced to determine the autonomic facial response\/flushing during social recognition testing. Whereas cognitive performance and salivary cortisol were comparable across human subjects and tests, the\n                    <jats:italic>Face Recognition Test<\/jats:italic>\n                    was associated with a characteristic\n                    <jats:italic>Reference Index<\/jats:italic>\n                    profile. Infrared thermography may have potential for discriminating disturbed social behaviors.\n                  <\/jats:p>","DOI":"10.1096\/fba.2019-00085","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T12:21:00Z","timestamp":1573734060000},"page":"18-32","source":"Crossref","is-referenced-by-count":8,"title":["Vascular response to social cognitive performance measured by infrared thermography: A translational study from mouse to man"],"prefix":"10.1096","volume":"2","author":[{"given":"Jan","family":"Seidel","sequence":"first","affiliation":[{"name":"Clinical Neuroscience Max Planck Institute of Experimental Medicine G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Bockhop","sequence":"additional","affiliation":[{"name":"Clinical Neuroscience Max Planck Institute of Experimental Medicine G\u00f6ttingen 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