{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:56:11Z","timestamp":1771656971668,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FASEB BioAdvances"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Duchenne muscular dystrophy (DMD) is a genetic disorder that results in the absence of dystrophin, a cytoskeletal protein. Individuals with this disease experience progressive muscle destruction, which leads to muscle weakness. Studies have been conducted to find solutions for the relief of individuals with this disease, several of which have shown that utrophin, a protein closely related to dystrophin, when overexpressed in <jats:italic>mdx<\/jats:italic> neonatal mice (the murine model of DMD), is able to prevent the progressive muscle destruction observed in the absence of dystrophin. Furthermore, recent studies have shown that L\u2010arginine induces utrophin upregulation in adult <jats:italic>mdx<\/jats:italic> mice. We hypothesized that L\u2010arginine treatment also induces utrophin upregulation to prevent the development of muscle weakness in neonatal <jats:italic>mdx<\/jats:italic> mice. Hence, L\u2010arginine should also prevent progressive muscle destruction via utrophin upregulation in <jats:italic>mdx<\/jats:italic> neonatal mice. <jats:italic>Mdx<\/jats:italic> neonatal mice were injected intraperitoneally daily with 800\u00a0mg\/kg of L\u2010arginine for 6\u00a0weeks, whereas control mice were injected with a physiological saline. The following experiments were performed on the tibialis anterior (TA) muscle: muscle contractility and resistance to mechanical stress; central nucleation and peripheral nucleation, utrophin, and creatine kinase quantification as well as a nitric oxide (NO) assay. Our findings show that early administration of L\u2010arginine in <jats:italic>mdx<\/jats:italic> neonatal mice prevents the destruction of the tibialis anterior (TA) muscle. However, this improvement was related to nitric oxide (NO) production rather than the expected utrophin upregulation.<\/jats:p>","DOI":"10.1096\/fba.2020-00104","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T11:33:38Z","timestamp":1619696018000},"page":"639-651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Early administration of L\u2010arginine in <i>mdx<\/i> neonatal mice delays the onset of muscular dystrophy in tibialis anterior (TA) muscle"],"prefix":"10.1096","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4437-0823","authenticated-orcid":false,"given":"Roy W. R.","family":"Dudley","sequence":"first","affiliation":[{"name":"Meakins Christie Laboratories McGill University Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain S.","family":"Comtois","sequence":"additional","affiliation":[{"name":"D\u00e9partement des Sciences de l\u2019Activit\u00e9 Physique Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al (UQAM Montreal QC Canada"},{"name":"Groupe de Recherche en Activit\u00e9 Physique Adapt\u00e9e UQAM Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"St\u2010Pierre","sequence":"additional","affiliation":[{"name":"D\u00e9partement des Sciences de l\u2019Activit\u00e9 Physique Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al (UQAM Montreal QC Canada"},{"name":"Groupe de Recherche en Activit\u00e9 Physique Adapt\u00e9e UQAM Montreal QC Canada"},{"name":"Centre de Recherche du CHU Sainte\u2010Justine Montr\u00e9al QC 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