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We have previously reported that direct\u2010current stimulation guides NSC migration toward the cathode in vitro. Accordingly, we set up a new method of transcranial direct\u2010current stimulation (tDCS), in which the cathodal electrode is placed on the ischemic hemisphere and anodal electrode on the contralateral hemisphere of rats subjected to ischemia\u2013reperfusion injury. We show that the application of this bilateral tDCS (BtDCS) promotes the migration of NSC\u2010derived neuroblasts from SVZ toward the cathode direction into poststroke striatum. Reversing the position of the electrodes blocks the effect of BtDCS on the migration of neuroblasts from SVZ. BtDCS protects against neuronal death and improves the functional recovery of stroke animals. Thus, the migration of NSC\u2010derived neuroblasts from SVZ toward poststroke brain region contributes to the effect of BtDCS against ischemia\u2010induced neuronal death, supporting a potential development of noninvasive BtDCS as an endogenous neurogenesis\u2010based stroke therapy.<\/jats:p>","DOI":"10.1096\/fba.2023-00017","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T09:31:49Z","timestamp":1684143109000},"page":"277-286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Bilateral transcranial direct\u2010current stimulation promotes migration of subventricular zone\u2010derived neuroblasts toward ischemic brain"],"prefix":"10.1096","volume":"5","author":[{"given":"Ruixue","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Pathology, Anyang Tumour Hospital The Affiliated Anyang Tumor Hospital of Henan University of Science and Technology  Anyang Henan China"},{"name":"Department of Physiology, School of Medicine Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anchun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhifeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyang","family":"Ren","sequence":"additional","affiliation":[{"name":"Institute of Neuroregeneration &amp; Neurorehabilitation, Department of Neurosurgery Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xujin","family":"Yao","sequence":"additional","affiliation":[{"name":"Institute of Neuroregeneration &amp; Neurorehabilitation, Department of Neurosurgery Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyi","family":"Kong","sequence":"additional","affiliation":[{"name":"Institute of Neuroregeneration &amp; Neurorehabilitation, Department of Neurosurgery Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenlong","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Neuroregeneration &amp; Neurorehabilitation, Department of Neurosurgery Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengyuan","family":"Che","sequence":"additional","affiliation":[{"name":"Central Laboratory, Department of Neurology Linyi People's Hospital, Qingdao University  Linyi Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, the Central Hospital of Wuhan tongji medical collof Huazhong University of Science &amp; Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1327-9851","authenticated-orcid":false,"given":"Qi","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine Wuhan University  Wuhan China"},{"name":"Institute of Neuroregeneration &amp; Neurorehabilitation, Department of Neurosurgery Qingdao University  Qingdao China"},{"name":"Qingdao Gui\u2010Hong Intelligent Medical Technology Co. 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