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Phytochelatins are metal\u2010binding peptides produced by plants. They are present in nearly all human diets, due to their ubiquity in plants. The urinary concentration of phytochelatin 2 among 143 adults was in the low micromolar range, and phytochelatin 2 and its metabolites had differential correlations with urinary selenium and toxic metals. Activities of ingested phytochelatins are largely undescribed. Observed urinary metal interactions were investigated further in cell and animal models. Selenite reacted with phytochelatin to form a phytochelatin selenotrisulfide, and the preformed selenotrisulfide showed increased selenium uptake by renal proximal tubule cells. In vivo studies further showed that oral phytochelatin increased renal selenium content and decreased lung cadmium in mice. Presence of phytochelatin in human urine combined with its function in selenium and heavy metal distribution present a new route by which diet may influence metal disposition and bioavailability.<\/jats:p>","DOI":"10.1096\/fba.2023-00050","type":"journal-article","created":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T03:54:01Z","timestamp":1691812441000},"page":"367-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Discovery of phytochelatins in human urine: Evidence for function in selenium disposition and protection against cadmium"],"prefix":"10.1096","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4670-1497","authenticated-orcid":false,"given":"Zachery R.","family":"Jarrell","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine Emory University School of Medicine  Atlanta Georgia 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