{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:57:17Z","timestamp":1788476237053,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T00:00:00Z","timestamp":1726876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FASEB BioAdvances"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The human placenta is a vital organ, encompassing many distinct cell types, that maintains the growth and development of the fetus and is essential for substance exchange, defense, synthesis, and immunity. Abnormalities in placental cells can lead to various pregnancy complications, but the mechanisms remain largely unclear. Single\u2010cell and spatial transcriptomics technologies have been developed in recent years to demonstrate placental cell heterogeneity and spatial molecular localization. Here, we review and summarize the current literature, demonstrating these technologies and showing the heterogeneity of various placenta cells and cell\u2013cell communication of normal human placenta, as well as placenta\u2010related diseases, such as preeclampsia, gestational diabetes mellitus, advanced maternal age, recurrent pregnancy loss, and placenta accreta spectrum disorders. Meanwhile, current weaknesses and future direction were discussed.<\/jats:p>","DOI":"10.1096\/fba.2024-00133","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T05:41:27Z","timestamp":1726897287000},"page":"503-518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Single\u2010cell and spatial transcriptomics: Discovery of human placental development and disease"],"prefix":"10.1096","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7284-6097","authenticated-orcid":false,"given":"Mi","family":"Tang","sequence":"first","affiliation":[{"name":"Chengdu Women's and Children's Central Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5692-6457","authenticated-orcid":false,"given":"Liling","family":"Xiong","sequence":"additional","affiliation":[{"name":"Obstetrics department, Chengdu Women's and Children's Central Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2510-3236","authenticated-orcid":false,"given":"Jianghui","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Chengdu Women's and Children's Central Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4361-905X","authenticated-orcid":false,"given":"Li","family":"Fan","sequence":"additional","affiliation":[{"name":"Chengdu Women's and Children's Central Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1057-4573","authenticated-orcid":false,"given":"Cheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Clinical laboratory, Chengdu Women's and Children's Central Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4789-5190","authenticated-orcid":false,"given":"Shimao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Obstetrics department, Chengdu Women's and Children's Central Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3929-810X","authenticated-orcid":false,"given":"Ying","family":"Jin","sequence":"additional","affiliation":[{"name":"Obstetrics department, Chengdu Women's and Children's Central Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9342-4547","authenticated-orcid":false,"given":"Er\u2010dan","family":"Luo","sequence":"additional","affiliation":[{"name":"Chengdu Women's and Children's Central Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8245-0683","authenticated-orcid":false,"given":"ShaSha","family":"Xing","sequence":"additional","affiliation":[{"name":"Chengdu Women's and Children's Central Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9805-221X","authenticated-orcid":false,"given":"Xiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Obstetrics department, Chengdu Women's and Children's Central Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,21]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.728291"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508035103"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.08.016"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.163428"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02597"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2020.53.8.130"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2014.006"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2639"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14049"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2020.05.006"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-022-01448-2"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201900221"},{"key":"e_1_2_15_14_1","first-page":"871","article-title":"Laser microdissection applications in histology: an open way to molecular studies","volume":"35","author":"Legr\u00e8s LG","year":"2019","journal-title":"Med Sci (Paris)"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-022-01409-2"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-018-0066-y"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.10.019"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-0763-4_6"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.78829"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12010087"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05869-0"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.199840"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2204069119"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.207597.116"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau4788"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0698-6"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.52004"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.1060298"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.10.024"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1710470114"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.655655"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2021.0211"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12968"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-023-00991-y"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1142273"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.679582"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B2101024"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/FM9.0000000000000135"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-020-00236-z"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.1044198"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2023.10.001"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.06.004"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-120219-083220"}],"container-title":["FASEB BioAdvances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fba.2024-00133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:25:55Z","timestamp":1761672355000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fba.2024-00133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,21]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1096\/fba.2024-00133"],"URL":"https:\/\/doi.org\/10.1096\/fba.2024-00133","archive":["Portico"],"relation":{},"ISSN":["2573-9832","2573-9832"],"issn-type":[{"value":"2573-9832","type":"print"},{"value":"2573-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,21]]},"assertion":[{"value":"2024-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}