{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T02:36:53Z","timestamp":1781663813894,"version":"3.54.5"},"reference-count":74,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FASEB BioAdvances"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Iron (Fe)\u2010deficiency (ID) and Fe\u2010deficiency anemia (IDA) are highly prevalent conditions and are of particular concern to maternal\u2013child health. ID and IDA are typically linked to nutritional deficiencies, but maternal exposure to heavy metals including cadmium (Cd) also leads to offspring with low levels of circulating Fe. Another comorbidity of ID and IDA is metabolic dysfunction\u2010associated steatotic liver disease (MASLD), a liver condition characterized by lipid accumulation and fibrosis. We have previously shown that maternal Cd exposure also leads to the development of MASLD in offspring. We hypothesized that providing Fe fortification would prevent Cd\u2010induced ID, which would in turn rescue offspring from growth restriction and MASLD. To test this, virgin dams were exposed to 30\u2009ppm of cadmium chloride (CdCl\n                    <jats:sub>2<\/jats:sub>\n                    ) in their drinking water during the preconception, gestation, and lactation periods. Fe fortification was supplied in the form of dietary ferric citrate, which amounted to two (2\u00d7) or five times (5\u00d7) the normal dietary Fe in standard chow. Our study provides evidence that perinatal Cd exposure does not prevent absorption of supplemental Fe, and that the chosen Fe supplementation dosages are sufficient to prevent Cd\u2010induced growth restriction, ID, IDA, and MASLD in offspring at postnatal day 21 (PND21). Our findings suggest that Fe supplementation may be a viable therapy to prevent these developmental effects of maternal Cd exposure.\n                  <\/jats:p>","DOI":"10.1096\/fba.2025-00045","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T11:25:52Z","timestamp":1750159552000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dietary Iron Supplementation Protects Against Growth Restriction and Metabolic Dysfunction\u2010Associated Steatotic Liver Disease in Perinatal Cadmium\u2010Exposed Mice"],"prefix":"10.1096","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4186-4537","authenticated-orcid":false,"given":"Rebecca","family":"Lichtler","sequence":"first","affiliation":[{"name":"Department of Biological Sciences North Carolina State University  Raleigh North Carolina USA"},{"name":"Center for Human Health and the Environment North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8873-1815","authenticated-orcid":false,"given":"Hannah","family":"Klossner","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6105-9128","authenticated-orcid":false,"given":"Nikia","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences North Carolina State University  Raleigh North Carolina USA"},{"name":"Center for Human Health and the Environment North Carolina State University  Raleigh North Carolina USA"},{"name":"Genetics Program North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2466-8617","authenticated-orcid":false,"given":"Cathrine","family":"Hoyo","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences North Carolina State University  Raleigh North Carolina USA"},{"name":"Center for Human Health and the Environment North Carolina State University  Raleigh North Carolina USA"},{"name":"Genetics Program North Carolina State University  Raleigh North Carolina USA"},{"name":"Toxicology Program North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8564-4224","authenticated-orcid":false,"given":"Michael","family":"Cowley","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences North Carolina State University  Raleigh North Carolina USA"},{"name":"Center for Human Health and the Environment North Carolina State University  Raleigh North Carolina USA"},{"name":"Genetics Program North Carolina State University  Raleigh North Carolina USA"},{"name":"Toxicology Program North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apgeochem.2019.104388"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0147\u20106513(83)90050\u20107"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201052234\u2010w"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.12.096"},{"key":"e_1_2_9_6_1","unstructured":"WHO \u201cExposure to Cadmium: A Major Public Health Concern \u201d(2019) https:\/\/www.who.int\/publications\/i\/item\/WHO\u2010CED\u2010PHE\u2010EPE\u201019\u20104\u20103."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.2002.9505"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8mt00174j"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJERPH17113782"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics11070641"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2020.07.005"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfr100"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201049807\u20105"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25020763"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-22023-9_15"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753\u20104887.2011.00432.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2015.2.10289"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.64800"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011\u2010018\u20101590\u20109"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011\u2010014\u20100223\u20101"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2011.03.007"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/09603123.2021.1929872"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/sci5\/5007983"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.146006"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1385\/BTER:96:1\u20103:217"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ECOENV.2023.114726"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605\u2010013\u20102210\u20109"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000282080"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010005\u20109017\u20102"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.2131\/fts.3.257"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.FCT.2023.113807"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfac106"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2004.12.009"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920012799320446"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfv149"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1427787"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3961\/jpmph.21.435"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.43.19"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17010138"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143\u20104004(88)90071\u20109"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.7570\/jomes23052"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvad165"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.11.017"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201089991\u2010x"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.10.017"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2022.2088173"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201095630\u20102"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14081653"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2019.11.003"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9040338"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.055"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1369\/0022155414545787"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12764"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1978.10667306"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2023.09.009"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10653\u2010021\u201001129\u20100"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119946045.ch33"},{"key":"e_1_2_9_59_1","volume-title":"Modern Nutrition in Health and Disease","author":"Ross C. A.","year":"2014"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/109.9.1640"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476\u20109255\u20102\u201014"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052719"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2009.04.008"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.24401"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1104431"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph14010058"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1159\/000480741"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10050601"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.19\u201011\u2010e690"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052\u2010022\u201001216\u20107"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2023.116636"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2016.02.029"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfac027"},{"key":"e_1_2_9_74_1","first-page":"340","article-title":"The Cardiomyopathy of Iron Deficiency","volume":"33","author":"Hegde N.","year":"2006","journal-title":"Texas Heart Institute Journal"},{"key":"e_1_2_9_75_1","unstructured":"Committee on Obstetrics Practice Committee Opinion: Lead Screening During Pregnancy and Lactation Report No.: 533 Washington DC(2012)."}],"container-title":["FASEB BioAdvances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fba.2025-00045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:38:01Z","timestamp":1761665881000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fba.2025-00045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,17]]},"references-count":74,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1096\/fba.2025-00045"],"URL":"https:\/\/doi.org\/10.1096\/fba.2025-00045","archive":["Portico"],"relation":{},"ISSN":["2573-9832","2573-9832"],"issn-type":[{"value":"2573-9832","type":"print"},{"value":"2573-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,17]]},"assertion":[{"value":"2025-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70027"}}