{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T05:25:03Z","timestamp":1769577903335,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["24\u201025\u201000138"],"award-info":[{"award-number":["24\u201025\u201000138"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FASEB BioAdvances"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The spleen is one of the key organs of the immune system that is involved in both innate and adaptive immunity. Splenectomy (SE) is surgery with many risks, including sepsis, thrombosis, and malignancy. In this regard, studies into the potential regeneration of the spleen and restoring its structure and functions are important. As in the past, heterotopic spleen transplantation regenerates the spleen structure after 30\u2009days. This study assessed the impact of heterotopic spleen regeneration on tumor growth. We used two animal models. In the first, animals had SE. In the second, animals had SE and subcutaneous transplantation (ST) of spleen fragments. These animals, as well as intact animals, were transplanted under the skin with tumor cells to obtain a subcutaneous model of tumor growth. The results showed that while there was no significant effect on tumor growth at 15\u2009days, there was a decrease in tumor cell proliferation rate. Spleen regeneration stimulated early occupancy of the tumor niche by macrophages, as well as influx of CD4+ T\u2010lymphocytes and B\u2010lymphocytes into the tumor, while infiltration of CD8+ T\u2010lymphocytes was suppressed. Thus, the effects of regenerating spleen on tumor growth that we have demonstrated require further investigation at longer follow\u2010up periods.<\/jats:p>","DOI":"10.1096\/fba.2025-00254","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T09:25:11Z","timestamp":1767950711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Heterotopic Spleen Regeneration on Tumor Growth"],"prefix":"10.1096","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7721-6120","authenticated-orcid":false,"given":"Daria","family":"Artemova","sequence":"first","affiliation":[{"name":"Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution \u201cPetrovsky National Research Centre of Surgery\u201d  Moscow Russia"},{"name":"Research Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University)  Moscow Russia"},{"name":"Petrovsky Medical University  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2392-4439","authenticated-orcid":false,"given":"Andrey","family":"Elchaninov","sequence":"additional","affiliation":[{"name":"Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution \u201cPetrovsky National Research Centre of Surgery\u201d  Moscow Russia"},{"name":"Petrovsky Medical University  Moscow Russia"},{"name":"National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9158-1933","authenticated-orcid":false,"given":"Anna","family":"Soboleva","sequence":"additional","affiliation":[{"name":"Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution \u201cPetrovsky National Research Centre of Surgery\u201d  Moscow Russia"},{"name":"Research Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University)  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4344-8943","authenticated-orcid":false,"given":"Irina","family":"Arutyunyan","sequence":"additional","affiliation":[{"name":"Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution \u201cPetrovsky National Research Centre of Surgery\u201d  Moscow Russia"},{"name":"Research Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University)  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8650-8240","authenticated-orcid":false,"given":"Polina","family":"Vishnyakova","sequence":"additional","affiliation":[{"name":"Research Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University)  Moscow Russia"},{"name":"National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. 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