{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T16:01:48Z","timestamp":1784995308126,"version":"3.55.0"},"reference-count":5,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FASEB BioAdvances"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Telomere repeat\u2010binding factor 2 (Trf2) is essential for protecting our telomeres. While Trf2 global deletion is lethal, its role in organ\u2010specific development, particularly in the heart, remains less understood. In this study, we investigated the role of Trf2 in cardiac development and function. Our studies reveal that cardiomyocyte (CM)\u2010specific loss of Trf2 leads to profound defects in heart morphology, including impaired ventricular wall formation and compromised CM proliferation, concurrent with no CM telomere length attrition. Further, in\u00a0vivo functional assessment and molecular analyses of CM\u2010Trf2 deficient ventricles revealed severe cardiac dysfunction and, interestingly, altered nuclear envelope gene expression. Our work provides new insights into the essential role of Trf2 in heart development and function and potential avenues for therapeutic intervention targeting telomere biology.<\/jats:p>","DOI":"10.1096\/fba.2026-00129","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T14:18:24Z","timestamp":1783088304000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Essential Role for Telomeric Repeat\u2010Binding Factor 2 in Cardiac Development and Function"],"prefix":"10.1096","volume":"8","author":[{"given":"Ali","family":"Hakim Shoushtari","sequence":"first","affiliation":[{"name":"Department of Medicine Vascular Medicine Institute  Pittsburgh Pennsylvania USA"},{"name":"Department of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysenure","family":"Danis","sequence":"additional","affiliation":[{"name":"Department of Medicine Vascular Medicine Institute  Pittsburgh Pennsylvania USA"},{"name":"Department of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Wayne","family":"Stoner","sequence":"additional","affiliation":[{"name":"Department of Medicine Vascular Medicine Institute  Pittsburgh Pennsylvania USA"},{"name":"Department of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Medicine Center for Metabolism and Mitochondrial Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Baust","sequence":"additional","affiliation":[{"name":"Department of Medicine Vascular Medicine Institute  Pittsburgh Pennsylvania USA"},{"name":"Department of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Medicine Center for Metabolism and Mitochondrial Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Sebastiani","sequence":"additional","affiliation":[{"name":"Department of Medicine Vascular Medicine Institute  Pittsburgh Pennsylvania USA"},{"name":"Department of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Medicine Center for Metabolism and Mitochondrial Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paramesha","family":"Bugga","sequence":"additional","affiliation":[{"name":"Department of Medicine Vascular Medicine Institute  Pittsburgh Pennsylvania USA"},{"name":"Department of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Medicine Center for Metabolism and Mitochondrial Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet R.","family":"Manning","sequence":"additional","affiliation":[{"name":"Department of Medicine Vascular Medicine Institute  Pittsburgh Pennsylvania USA"},{"name":"Department of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Medicine Center for Metabolism and Mitochondrial Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bellina A. S.","family":"Mushala","sequence":"additional","affiliation":[{"name":"Department of Medicine Vascular Medicine Institute  Pittsburgh Pennsylvania USA"},{"name":"Department of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Medicine Center for Metabolism and Mitochondrial Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha","family":"Bhattarai","sequence":"additional","affiliation":[{"name":"Department of Medicine Vascular Medicine Institute  Pittsburgh Pennsylvania USA"},{"name":"Department of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Medicine Center for Metabolism and Mitochondrial Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imad","family":"Al Ghouleh","sequence":"additional","affiliation":[{"name":"The Warren Alpert Medical School of Brown University  Providence Rhode Island USA"},{"name":"Health Cardiovascular Institute  Providence Rhode Island USA"},{"name":"Providence VA Medical Center  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5929-0928","authenticated-orcid":false,"given":"Iain","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Medicine Vascular Medicine Institute  Pittsburgh Pennsylvania USA"},{"name":"Department of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Medicine Center for Metabolism and Mitochondrial Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Sharifi\u2010Sanjani","sequence":"additional","affiliation":[{"name":"Department of Medicine Vascular Medicine Institute  Pittsburgh Pennsylvania USA"},{"name":"Department of Medicine Center for Metabolism and Mitochondrial Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2015.05.007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.09.038"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2209967120"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005086"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24849-4"}],"container-title":["FASEB BioAdvances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fba.2026-00129","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fba.2026-00129","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fba.2026-00129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T15:09:34Z","timestamp":1784992174000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fba.2026-00129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1096\/fba.2026-00129"],"URL":"https:\/\/doi.org\/10.1096\/fba.2026-00129","archive":["Portico"],"relation":{},"ISSN":["2573-9832","2573-9832"],"issn-type":[{"value":"2573-9832","type":"print"},{"value":"2573-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70133"}}