{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:38:02Z","timestamp":1793025482877,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FASEB BioAdvances"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Stroke is not merely a cerebrovascular event but a systemic disorder with multi\u2010organ implications, including the liver and kidneys. Despite this growing body of knowledge, significant gaps persist. Most studies characterizing poststroke renal, hepatic, and hematological profiles originate from high\u2010income settings, with limited data from sub\u2010Saharan African populations who face distinct genetic, environmental, and healthcare access challenges. A case\u2013control study was conducted at the Tamale Teaching Hospital between March and September 2025. The study involved 69 participants, aged 31\u201378\u2009years, of whom 20 (29.0%) were stroke survivors (cases). Of the 69 participants, 39 (56.5%) were female. A single venous blood sample was collected and analyzed for full blood count, liver and renal function variables. Bivariate analysis revealed no significant differences in liver and renal function; however, the mean cell volume (MCV [fL]), the red cell distribution width (RDW\u2010CV [%]), eosinophils (%), and plateletcrit (PCT [%]) were lower, whereas the mean cell hemoglobin concentration (MCHC [g\/dL]) was higher in the stroke group. After adjusting for confounders, including body mass index (BMI) and occupation, the indirect bilirubin level was 0.143\u2009mmol\/L higher in the stroke group. In addition, the MCHC was 0.398\u2009g\/dL higher, while the hematocrit (HCT), MCV, and RDW\u2010CV were lower in the stroke group by 0.206 (%), 0.121 (fL), and 0.514 (%), respectively. This study suggests that stroke survivors exhibit distinct hematological profiles, characterized by alterations in RBC morphology and possibly low\u2010grade hemolysis or altered bilirubin metabolism independent of major liver or renal dysfunction. These changes may reflect the persistent systemic inflammation, oxidative stress, and erythropoietic adaptation following a stroke.<\/jats:p>","DOI":"10.1096\/fba.2026-00172","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:10:01Z","timestamp":1790349001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hepatorenal and Full Blood Count Profiles of Stroke Survivors Compared With Controls: A Case\u2013Control Study"],"prefix":"10.1096","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3594-6077","authenticated-orcid":false,"given":"Moses","family":"Banyeh","sequence":"first","affiliation":[{"name":"Department of Clinical Chemistry University for Development Studies  Tamale Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian Ayimpoka","family":"Atindaana","sequence":"additional","affiliation":[{"name":"Department of Biomedical 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