{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:05:26Z","timestamp":1790247926081,"version":"4.1.0"},"reference-count":71,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FASEB BioAdvances"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A long non\u2010coding RNA (lncRNA) known as the X\u2010inactivation specific transcript (\n                    <jats:italic>XIST<\/jats:italic>\n                    ) plays a central role in X chromosome inactivation\u2014a transcriptional process that silences one of the two X chromosomes in females to ensure dosage compensation between males and females. Much research has been conducted on how\n                    <jats:italic>XIST<\/jats:italic>\n                    regulates X chromosome transcription critical to embryonic development, but recent studies suggest a non\u2010canonical role for\n                    <jats:italic>XIST<\/jats:italic>\n                    in regulating cancer stem cells and cellular plasticity. As cell adhesion and adhesome genes are integral to the regulation of cancer stemness, we explored the previously unrecognized link between\n                    <jats:italic>XIST<\/jats:italic>\n                    and the adhesome network. By performing gene expression and gene ontology analysis on\n                    <jats:italic>XIST<\/jats:italic>\n                    \u2010knockdown ovarian cancer cells, our study showed that\n                    <jats:italic>XIST<\/jats:italic>\n                    loss altered adhesome gene expression and downstream adhesion pathways. Using Genotype\u2010Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) datasets, we identified distinct correlations between\n                    <jats:italic>XIST<\/jats:italic>\n                    lncRNA and adhesome genes across normal and cancer tissue samples, which are associated with cell stemness. Furthermore, network analysis suggests that\n                    <jats:italic>XIST<\/jats:italic>\n                    may interact with specific adhesome genes within the cell nucleus. This interaction may have significant functional implications, as demonstrated by the hazard ratio analysis of\n                    <jats:italic>XIST<\/jats:italic>\n                    and adhesome gene expression in relation to clinical outcomes. Overall, our results show that among well\u2010annotated functional lncRNAs,\n                    <jats:italic>XIST<\/jats:italic>\n                    appears to be a modulator strongly associated with the adhesome network and cell stemness. Our findings thus support a novel link between lncRNA\u2010mediated epigenetic regulation of cell adhesion genes, highlighting\n                    <jats:italic>XIST<\/jats:italic>\n                    as a key regulator contributing to the adhesome network.\n                  <\/jats:p>","DOI":"10.1096\/fba.2026-00185","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T08:11:05Z","timestamp":1789805465000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>\n                      <i>XIST<\/i>\n                    <\/scp>\n                    Is a Key Modulator Associated With the Adhesome Network"],"prefix":"10.1096","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1463-9552","authenticated-orcid":false,"given":"Dongning","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Developmental and Cell Biology University of California  Irvine California USA"},{"name":"Chao Family Comprehensive Cancer Center University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0891-7249","authenticated-orcid":false,"given":"Nolan","family":"Origer","sequence":"additional","affiliation":[{"name":"Chao Family Comprehensive Cancer Center University of California  Irvine California USA"},{"name":"Department of Biomedical Engineering University of California  Irvine California USA"},{"name":"The NSF\u2010Simons Center for Multiscale Cell Fate Research University of California  Irvine California USA"},{"name":"Edwards Lifesciences Foundation, Cardiovascular Innovation and Research Center University of California  Irvine California USA"},{"name":"Sue and Bill Gross Stem Cell Research Center University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0044-6403","authenticated-orcid":false,"given":"Sha","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Developmental and Cell Biology University of California  Irvine California USA"},{"name":"Chao Family Comprehensive Cancer Center University of California  Irvine California USA"},{"name":"Department of Systems Biology University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5197-3684","authenticated-orcid":false,"given":"Timothy L.","family":"Downing","sequence":"additional","affiliation":[{"name":"Chao Family Comprehensive Cancer Center University of California  Irvine California USA"},{"name":"Department of Biomedical Engineering University of California  Irvine California USA"},{"name":"The NSF\u2010Simons Center for Multiscale Cell Fate Research University of California  Irvine California USA"},{"name":"Edwards Lifesciences Foundation, Cardiovascular Innovation and Research Center University of California  Irvine California USA"},{"name":"Sue and Bill Gross Stem Cell Research Center University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Epigenetics, Second Edition","author":"Allis C. 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