{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:05:21Z","timestamp":1790247921023,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2024NSFSC0695"],"award-info":[{"award-number":["2024NSFSC0695"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FASEB BioAdvances"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Diminished ovarian reserve (DOR) presents a formidable challenge for assisted reproduction technology, as affected patients typically exhibit reduced oocytes and embryos during in\u00a0vitro fertilization and embryo transfer (IVF\u2010ET), which may ultimately lead to compromised clinical pregnancy rate. Although growth hormone (GH) supplementation has shown clinical efficacy in improving the outcomes of IVF\u2010ET, the precise molecular mechanisms underlying its ability to enhance ovarian reserve have remained poorly characterized. In this study, a cisplatin\u2010induced DOR mice model was established via intraperitoneal cisplatin administration. GH was subsequently evaluated at four dose levels over a 21\u2010day intervention period. Comprehensive assessments included quantitative follicular histomorphometry, serum hormone profiling, and whole\u2010transcriptome analysis of ovarian tissue. GH treatment significantly increased the number of primary and secondary follicles in a dose\u2010dependent manner (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), while concurrently reducing atretic follicle counts in the medium\u2010 and high\u2010dose GH groups compared to the DOR group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Furthermore, GH treatment restored hormonal balance, characterized by decreased follicle\u2010stimulating hormone (FSH) and increased estradiol (E\n                    <jats:sub>2<\/jats:sub>\n                    ) and anti\u2010m\u00fcllerian hormone (AMH) levels (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Transcriptomic analysis revealed that differentially expressed genes (DEGs) between the DOR and negative control (NC) groups were primarily associated with mitochondrial energy metabolism and the reproductive endocrine system, with functional enrichment in ribosome biogenesis, oxidative phosphorylation, and thermogenesis. In contrast, DEGs between the high\u2010dose GH and DOR groups were predominantly enriched in pathways related to immunity, mitochondrial function, protein synthesis, and extracellular matrix\u2010receptor interactions. In conclusion, GH can restore the ovarian reserve in cisplatin\u2010induced DOR mice in a dose\u2010dependent manner, potentially by modulating the genetic networks involved in energy metabolism, oxidative homeostasis, and protein synthesis.\n                  <\/jats:p>","DOI":"10.1096\/fba.2026-00193","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:47:42Z","timestamp":1790156862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Growth Hormone Reverses Cisplatin\u2010Induced Ovarian Reserve Depletion in Mice: Transcriptomic Elucidation of Mitochondrial Metabolic Reprogramming and Protein Synthesis Regulation"],"prefix":"10.1096","volume":"8","author":[{"given":"Tianhong","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Medical Genetics and Prenatal Diagnosis Sichuan Provincial Women's and Children's Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8609-9413","authenticated-orcid":false,"given":"Niu","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine Sichuan Provincial Women's and Children's Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Xiong","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine Sichuan Provincial Women's and Children's Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine Sichuan Provincial Women's and Children's Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajing","family":"Wei","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine Sichuan Provincial Women's and Children's Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furui","family":"Chen","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine Sichuan Provincial Women's and Children's Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College  Chengdu Sichuan China"},{"name":"Department of Obstetrics Sichuan Jinxin Xinan Women's and Children's Hospital  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Qiu","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine Sichuan Provincial Women's and Children's Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyi","family":"Long","sequence":"additional","affiliation":[{"name":"Center of Laboratory Medicine Sichuan Provincial Women's and Children's Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianwen","family":"Luo","sequence":"additional","affiliation":[{"name":"Center of Laboratory Medicine Sichuan Provincial Women's and Children's Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Li\u2010Ling","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics West China Second University 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