{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:31:23Z","timestamp":1789378283096,"version":"build-2803163510"},"reference-count":69,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Unilateral injection into the right substantia nigra of the catecholaminergic neurotoxin 6\u2010hydroxydopamine (6\u2010OHDA) produces extensive loss of dopaminergic cells (\u2018hemi\u2010parkinsonian rat\u2019). The pineal hormone melatonin, which is a potent antioxidant against different reactive oxygen species and has been reported to be neuroprotective\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    , was evaluated for potential anti\u2010Parkinson effects in this model. Imbalance in dopaminergic innervation between the striata produced by intranigral administration of 6\u2010OHDAresults in a postural asymmetry causing rotation away from the nonlesioned side. Melatonin given systemically prevented apomorphine\u2010induced circling behavior in 6\u2010OHDA\u2010lesioned rats. Reduced activity of mitochondrial oxidative phosphorylation enzymes has been suggested in some neurodegenerative diseases; in particular, selective decrease in complex I activity is observed in the substantia nigra of Parkinson's disease patients. Analysis of mitochondrial oxidative phosphorylation enzyme activities in nigral tissue from 6\u2010OHDA\u2010lesioned rats by a novel BN\u2010PAGE histochemical procedure revealed a clear loss of complex I activity, which was protected against in melatonintreated animals. A good correlation between behavioral parameters and enzymatic (complex I) analysis was observed independent of melatonin administration. A deficit in mitochondrial complex I could conceivably contribute to cell death in parkinsonism via free radical mechanisms, both directly via reactive oxygen species production and by decreased ATP synthesis and energy failure. Melatonin may have potential utility in the treatment of neurodegenerative disorders where oxidative stress is a participant.\u2014Dabbeni\u2010Sala, F., Di Santo, S., Franceschini, D., Skaper, S. D., Giusti, P. Melatonin protects against 6\u2010OHDA\u2010induced neurotoxicity in rats: a role for mitochondrial complex I activity.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    15, 164\u2013170 (2001)\n                  <\/jats:p>","DOI":"10.1096\/fj.00-0129com","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T19:03:10Z","timestamp":1027710190000},"page":"164-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":156,"title":["Melatonin protects against 6\u2010OHDA\u2010induced neurotoxicity in rats: a role for mitochondrial complex I activity"],"prefix":"10.1096","volume":"15","author":[{"given":"FEDERICA","family":"DABBENI-SALA","sequence":"first","affiliation":[{"name":"Department of Pharmacology University of Padova  35131 Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STEFANIA","family":"DI Santo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of Padova  35131 Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAVIDE","family":"FRANCESCHINI","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of Padova  35131 Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STEPHEN","family":"D. 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