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Using PF1022A ligand immunoscreening of a cDNA library constructed from the parasitic nematode\n                    <jats:italic>Haemonchus contortus<\/jats:italic>\n                    , we identified a 3539 bp cDNA encoding a novel orphan heptahelical transmembrane 110 kDa\u2010receptor, termed HC110\u2010 R, similar to the mammalian G\u2010protein coupled receptor latrophilin. HC110\u2010R is localized at plasma membranes and in intracellular vesicles of HC110\u2010R\u2010transfected HEK\u2010293 cells. The ligand of latrophilin, a\u2010latrotoxin (LTX), binds to the extracellular\n                    <jats:italic>N<\/jats:italic>\n                    \u2010terminal region of HC110\u2010 R and induces influx of external Ca\n                    <jats:sup>2+<\/jats:sup>\n                    through Cd\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010 and nifedipine\u2010blockable Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels. PF1022A also binds to the\n                    <jats:italic>N<\/jats:italic>\n                    \u2010terminus of HC110\u2010R and acts as an antagonist to LTX signaling in HC110\u2010R transfected HEK\u2010293 cells.\n                  <\/jats:p>","DOI":"10.1096\/fj.00-0664fje","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T19:03:10Z","timestamp":1027710190000},"page":"1332-1334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Latrophilin\u2010like receptor from the parasitic nematode\n                    <i>Haemonchus contortus<\/i>\n                    as target for the anthelmintic depsipeptide PF1022A"],"prefix":"10.1096","volume":"15","author":[{"given":"Beate","family":"Saeger","sequence":"first","affiliation":[{"name":"Division of Molecular Parasitology and Center for Biological and Medical Research Heinrich-Heine-University 40225 D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Schmitt-Wrede","sequence":"additional","affiliation":[{"name":"Division of Molecular Parasitology and Center for Biological and Medical Research Heinrich-Heine-University 40225 D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Dehnhardt","sequence":"additional","affiliation":[{"name":"Medical Institute of Environmental Hygiene at the Heinrich-Heine-University 40225 D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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