{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:26:23Z","timestamp":1773458783314,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006379","name":"Office of Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006379","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY-11998"],"award-info":[{"award-number":["EY-11998"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY-13238"],"award-info":[{"award-number":["EY-13238"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Extraocular muscles (EOMs) are specialized skeletal muscles that are constantly active, generate low levels of force for cross sectional area, have rapid contractile speeds, and are highly fatigue resistant. The neuronal isoform of nitric oxide synthase (nNOS) is concentrated at the sarcolemma of fast\u2010twitch muscles fibers, and nitric oxide (NO) modulates contractility. This study evaluated nNOS expression in EOM and the effect of NO modulation on lateral rectus muscle's contractility. nNOS activity was highest in EOM compared with diaphragm, extensor digitorum longus, and soleus. Neuronal NOS was concentrated to the sarcolemma of orbital and global singly innervated fibers, but not evident in the multi\u2010innervated fibers. The\n                    <jats:italic>N<\/jats:italic>\n                    <jats:sup>G<\/jats:sup>\n                    \u2010nitro\u2010\n                    <jats:sc>L<\/jats:sc>\n                    \u2010arginine methyl ester (\n                    <jats:sc>L<\/jats:sc>\n                    \u2010NAME, a NOS inhibitor), increased submaximal tetanic and peak twitch forces. The NO donors S\u2010nitroso\u2010N\u2010acetylcys\u2010teine (SNAC) and spermineNONOate reduced submaximal tetanic and peak twitch forces. The effect of NO on the contractile force of lateral rectus muscle is greater than previously observed on other skeletal muscle. NO appears more important in modulating contraction of EOM compared with other skeletal muscles, which could be important for the EOM's specialized role in generation of eye movements.\u2014Richmonds, C. R., Kaminski, H. J. Nitric oxide synthase expression and effects of nitric oxide modulation on contractility of rat extraocular muscle.\n                    <jats:italic>FASEB J<\/jats:italic>\n                    . 15, 1764\u20131770 (2001)\n                  <\/jats:p>","DOI":"10.1096\/fj.00-0899com","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T19:03:10Z","timestamp":1027710190000},"page":"1764-1770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Nitric oxide synthase expression and effects of nitric oxide modulation on contractility of rat extraocular muscle"],"prefix":"10.1096","volume":"15","author":[{"given":"CHELLIAH R.","family":"RICHMONDS","sequence":"first","affiliation":[{"name":"Departments of Neurology Case Western Reserve University School of Medicine Louis Stokes Cleveland Veterans Affairs Medical Center University Hospitals of Cleveland Cleveland Ohio 44106 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HENRY J.","family":"KAMINSKI","sequence":"additional","affiliation":[{"name":"Departments of Neurosciences Case Western Reserve University School of Medicine Louis Stokes Cleveland Veterans Affairs Medical Center University Hospitals of Cleveland Cleveland Ohio 44106 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.1.30"},{"key":"e_1_2_6_3_1","first-page":"321","article-title":"Ocular muscles: physiology and structure-function correlations","volume":"237","author":"Ruff R. L.","year":"1989","journal-title":"Bull. Soc. Belg. Ophthalmol."},{"key":"e_1_2_6_4_1","first-page":"33","volume-title":"Neuroanatomy of the Oculomotor System","author":"Spencer R. F.","year":"1988"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020074"},{"key":"e_1_2_6_6_1","first-page":"1280","article-title":"Evidence for active control of rectus extraocular muscle pulleys","volume":"41","author":"Demer J. L.","year":"2000","journal-title":"Invest. Oph-thalmol. Vis. Sci."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91010-C"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01753992"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.101.2.618"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1989.61.1.116"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.19.11204"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/372546a0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.1824"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","unstructured":"Kaminski H. J. andAndrade F. H.(2001)Nitric oxide: biologic effects on muscle and role in muscle disease.Neuromusc. Disord.In press","DOI":"10.1016\/S0960-8966(01)00215-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.1.209"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1974.sp010434"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020073"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1977.tb06098.x"},{"key":"e_1_2_6_19_1","first-page":"345","volume-title":"Handbook of Physiology, Section 1: The Nervous System","author":"Burke R.","year":"1981"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-14-05463.1998"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90471-9"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(99)00035-4"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.7.2811"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.17.7797"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(96)00675-0"},{"key":"e_1_2_6_26_1","volume-title":"Muscle Biopsy: A Laboratory Investigation","author":"Loughlin M.","year":"1993"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(05)80055-4"},{"key":"e_1_2_6_28_1","first-page":"184","article-title":"Density and composition of mammalian muscle","volume":"9","author":"Mendez J.","year":"1960","journal-title":"Metabolism"},{"key":"e_1_2_6_29_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0076-6879(96)69028-4","volume-title":"Nitric Oxide, Part B: Physiological and Pathological Processes","author":"Kroncke K.-D.","year":"1996"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.12.2149"},{"key":"e_1_2_6_31_1","first-page":"267","volume-title":"Methods in Enzymology","author":"Christen S.","year":"1996"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.1998.0303f.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1152\/ajplegacy.1967.212.1.92","article-title":"Relaxing effect of spermine and spermidine on intact and glycerol-treated muscle","volume":"212","author":"De Meis L.","year":"1967","journal-title":"Am. J. Physiol."},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(99)00106-2"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90269-0"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi9909445"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1139\/y94-152"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1139\/y97-096"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1139\/y95-096"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(97)00417-0"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00581270"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(20000201\/15)48:3\/4<192::AID-JEMT7>3.0.CO;2-J"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004240050391"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)00829-0"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.11.5604"},{"key":"e_1_2_6_46_1","first-page":"252a","article-title":"Simultaneous Ca binding to and occlusion within the sarcoplasmic reticulum Ca-pump which contradicts the E1-E2 model","volume":"59","author":"Meszaros L. G.","year":"1991","journal-title":"Biophys. J."},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.577bn.x"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.271.5.C1424"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06188.x"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.00-0899com","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.00-0899com","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.00-0899com","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:33:13Z","timestamp":1761694393000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.00-0899com"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["10.1096\/fj.00-0899com"],"URL":"https:\/\/doi.org\/10.1096\/fj.00-0899com","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8]]},"assertion":[{"value":"2000-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-08-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}