{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:13:19Z","timestamp":1788268399206,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Nitric oxide (NO) in the low nanomolar range acts as a transcellular messenger molecule to initiate regulatory and physiological responses in nearby target cells via binding to the soluble guanylate cyclase heme moiety. Higher NO concentrations, as synthesized by the inducible NO synthase (iNOS) during inflammatory processes, show additional effects: NO may react with O\n                    <jats:sub>2<\/jats:sub>\n                    , yielding nitrogen oxides like N\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    that are able to nitrosate thiols. A variety of proteins involved in very different functions of the cell contain cysteine\u2010Zn\n                    <jats:sup>2+<\/jats:sup>\n                    complexes. Effects of NO on different proteins containing cysteine\u2010Zn\n                    <jats:sup>2+<\/jats:sup>\n                    domains and playing essential roles during transcription, protein folding, and proteolysis are discussed. It is suggested that iNOS\u2010derived NO acts as a signal molecule targeting cysteine\u2010Zn\n                    <jats:sup>2+<\/jats:sup>\n                    linkages, thus enabling cells to react toward nitrosative stress.\u2014Kr\u00f6ncke, K.\u2010D. Cysteine\u2013Zn\n                    <jats:sup>2+<\/jats:sup>\n                    complexes: unique molecular switches for inducible nitric oxide synthase\u2010derived NO.\n                    <jats:italic>FASEB J<\/jats:italic>\n                    . 15, 2503\u20132507 (2001)\n                  <\/jats:p>","DOI":"10.1096\/fj.01-0240hyp","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T19:03:24Z","timestamp":1027710204000},"page":"2503-2507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Cysteine\u2010Zn\n                    <sup>2+<\/sup>\n                    complexes: unique molecular switches for inducible nitric oxide synthase\u2010derived NO"],"prefix":"10.1096","volume":"15","author":[{"given":"KLAUS-D.","family":"KR\u00d6NCKE","sequence":"first","affiliation":[{"name":"Research Group Immunobiology Medical Department of the Heinrich-Heine-University of D\u00fcsseldorf D-40225 D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,11,1]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1998.00648.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.9.8.7768350"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1139\/o98-021"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.1.165"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.8.1703"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1564"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3440253"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0750266.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1042\/bj3540397","article-title":"Nitric oxide-dependent pro-oxidant and pro-apoptotic effect of metallothioneins in HL-60 cells challenged with cupric nitrilotriacetate","volume":"354","author":"Liu S. 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