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The high proliferation rate in the tumor deprived of proper vascularization would be balanced by cell death due to lack of diffusion of nutrients and oxygen. Matrix metalloproteinases (MMPs), angiogenic growth factors, and their receptors are the main targets of an increasing number of clinical trials approved to test the tolerance and therapeutic efficacy of antiangiogenic agents. We observed that a series of substances proposed as possible cancer chemopreventive agents show antiangiogenic properties when tested in in vitro and in vivo angiogenesis models. We demonstrated that N\u2010acetyl\n                    <jats:sc>\u2010L<\/jats:sc>\n                    \u2010cysteine is able to reduce the invasive and metastatic potential of melanoma cells, and to inhibit endothelial cell invasion by direct inhibition of MMP activity. We also showed that epigallocatechin gallate (EGCG), a flavonoid from green tea that possesses chemopreventive activity in experimental and epidemi\u2010ological studies, is a potent inhibitor of MMP\u20102 and MMP\u20109. Angiogenesis has also been demonstrated to be a target for nonsteroidal anti\u2010inflammatory drug che\u2010mopreventive activity. Based on these data, we hypothesize that other chemopreventive agents, including natural or synthetic retinoids, steroid hormone antagonists, peroxisome proliferator\u2010activated receptor \u03b3 li\u2010gands, vitamin D, and protease inhibitors, might have antiangiogenesis as an important mechanism of action, a novel concept we will term \u2018angioprevention\u2019. We analyze the mechanisms on how and why chemopreven\u2010tive agents could exert antiangiogenic effects aimed at controlling tumor growth, and their potential use in the clinic.\u2014Tosetti, F., Ferrari, N., De Flora, S., Albini, A. \u2018Angioprevention\u2019: angiogenesis is a common and key target for cancer chemopreventive agents.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    16, 2\u201314 (2002)\n                  <\/jats:p>","DOI":"10.1096\/fj.01-0300rev","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T19:03:24Z","timestamp":1027710204000},"page":"2-14","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":248,"title":["\u2018Angioprevention\u2019: angiogenesis is a common and key target for cancer chemopreventive agents"],"prefix":"10.1096","volume":"16","author":[{"given":"Francesca","family":"Tosetti","sequence":"first","affiliation":[{"name":"Molecular Biology Laboratory National Cancer Research Institute (IST) Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory National Cancer Research Institute (IST) Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvio","family":"De Flora","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Section of Hygiene and Preventive Medicine University of Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Albini","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory National Cancer Research Institute (IST) Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.133.2.275"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19971015)80:8 <1529::AID-CNCR2>3.0.CO;2-F"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/70928"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0958-1669(00)00153-1"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/37126"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80108-7"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)61026-X"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.3.525"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.2.94"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00040-X"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/70995"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00092-7"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.7.999"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/15145"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06313.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.9.1745"},{"key":"e_1_2_11_18_1","first-page":"2323","article-title":"Antioxidants reduce cyclooxy-genase-2 expression, prostaglandin production, and proliferation in colorectal cancer cells","volume":"58","author":"Chinery R.","year":"1998","journal-title":"Cancer Res."},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910610121"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/scbi.2000.0365"},{"key":"e_1_2_11_21_1","first-page":"1151","article-title":"N-Acetylcysteine inhibits endothelial cell invasion and angiogenesis while protecting from apoptosis","volume":"79","author":"Cai T.","year":"1999","journal-title":"Lab. 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