{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:23:09Z","timestamp":1791062589508,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2001,9,17]],"date-time":"2001-09-17T00:00:00Z","timestamp":1000684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2001,9,17]],"date-time":"2001-09-17T00:00:00Z","timestamp":1000684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Development of polarized immune responses controls resistance and susceptibility to many microorganisms. However, studies of several infectious, allergic, and autoimmune diseases have shown that chronic type\u20101 and type\u20102 cytokine responses can also cause significant morbidity and mortality if left unchecked. We used mouse cDNA microarrays to molecularly phenotype the gene expression patterns that characterize two disparate but equally lethal forms of liver pathology that develop in\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    infected mice polarized for type\u20101 and type\u20102 cytokine responses. Hierarchical clustering analysis identified at least three groups of genes associated with a polarized type\u20102 response and two linked with an extreme type\u20101 cytokine phenotype. Predictions about liver fibrosis, apoptosis, and granulocyte recruitment and activation generated by the microarray studies were confirmed later by traditional biological assays. The data show that cDNA microarrays are useful not only for determining coordinated gene expression profiles but are also highly effective for molecularly \u201cfingerprinting\u201d diseased tissues. Moreover, they illustrate the potential of genome\u2010wide approaches for generating comprehensive views on the molecular and biochemical mechanisms regulating infectious disease pathogenesis.\n                  <\/jats:p>","DOI":"10.1096\/fj.01-0306fje","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T19:03:24Z","timestamp":1027710204000},"page":"2545-2547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type\u20101 and type\u20102 cytokine\u2010mediated inflammatory reactions"],"prefix":"10.1096","volume":"15","author":[{"given":"Karl F.","family":"Hoffmann","sequence":"first","affiliation":[{"name":"Immunobiology Section Laboratory of Parasitic Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"McCarty","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology National Institutes of Allergy and Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Segal","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology National Institutes of Allergy and Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Chiaramonte","sequence":"additional","affiliation":[{"name":"Immunobiology Section Laboratory of Parasitic Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Hesse","sequence":"additional","affiliation":[{"name":"Immunobiology Section Laboratory of Parasitic Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Davis","sequence":"additional","affiliation":[{"name":"Immunobiology Section Laboratory of Parasitic Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen W.","family":"Cheever","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Meltzer","sequence":"additional","affiliation":[{"name":"Cancer Genetics Branch National Human Genome Research Institute at the National Institutes of Health Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert C. 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