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In this study, we examined the role of CCR4 in the chronic allergic airway response to live Aspergillus fumigatus spores, or conidia, in A. fumigatussensitized mice. After the conidia challenge, mice lacking CCR4 (CCR4\u2010\/\u2010 mice) exhibited significantly increased numbers of airway neutrophils and macrophages, and conidia were more rapidly eliminated from these mice compared with control CCR4 wild\u2010type (CCR4+\/+) mice. Significant airway hyperresponsiveness to intravenous methacholine was observed at day 3 in CCR4\u2010\/\u2010 mice, whereas at days 7 and 30, airway hyperresponsiveness was attenuated in these mice compared with control mice. A major reduction in peribronchial and airway eosinophilia was observed in CCR4\u2010\/\u2010 mice at all times after conidia challenge in contrast to CCR4+\/+ mice. Further, whole lung levels of interleukin (IL) 4 and IL\u20105 were significantly increased in CCR4\u2010\/\u2010 mice at day 3, whereas these Th2 cytokines and IL\u201013 were significantly decreased at day 30 in CCR4\u2010\/\u2010 mice compared with their wild\u2010type counterparts. Peribronchial fibrosis and goblet cell hyperplasia were similar in both groups of mice throughout the course of this model. In summary, CCR4 modulates both innate and acquired immune responses associated with chronic fungal asthma.<\/jats:p>","DOI":"10.1096\/fj.02-0193fje","type":"journal-article","created":{"date-parts":[[2002,9,30]],"date-time":"2002-09-30T13:43:21Z","timestamp":1033393401000},"page":"1313-1315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Airway hyperresponsiveness, but not airway remodeling, is attenuated during chronic pulmonary allergic responses to Aspergillus in CCR4\u2010\/\u2010 mice"],"prefix":"10.1096","volume":"16","author":[{"given":"Jane M.","family":"Schuh","sequence":"first","affiliation":[{"name":"Department of Pathology University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine A.","family":"Power","sequence":"additional","affiliation":[{"name":"Department of Pathology Serono Pharmaceutical Research Institute  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda E.","family":"Proudfoot","sequence":"additional","affiliation":[{"name":"Department of Pathology Serono Pharmaceutical Research Institute  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Kunkel","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas W.","family":"Lukacs","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory M.","family":"Hogaboam","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,6,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.3.1764"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.6.1890"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7613"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/23495"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2000.17713.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.9.1595"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.24.4.4360"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.270.33.19495","article-title":"Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line","volume":"270","author":"Power C. 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