{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T06:54:43Z","timestamp":1793170483268,"version":"4.5.0"},"reference-count":65,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,12,3]],"date-time":"2002-12-03T00:00:00Z","timestamp":1038873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:p>\n                    The 37\u2010kDa protein annexin 1 (Anx\u20101; lipocortin 1) has been implicated in the regulation of phagocytosis, cell signaling, and proliferation and is postulated to be a mediator of glucocorticoid action in inflammation and in the control of anterior pituitary hormone release. Here, we report that mice lacking the Anx\u20101 gene exhibit a complex phenotype that includes an altered expression of other annexins as well as of COX\u20102 and cPLA\n                    <jats:sub>2<\/jats:sub>\n                    . In carrageenin\u2010 or zymosan\u2010induced inflammation, Anx\u20101\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice exhibit an exaggerated response to the stimuli characterized by an increase in leukocyte emigration and IL\u20101\u03b2 generation and a partial or complete resistance to the antiinflammatory effects of glucocorticoids. Anx\u20101\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    polymorphonuclear leucocytes exhibited increased spontaneous migratory behavior\n                    <jats:italic>in vivo<\/jats:italic>\n                    whereas\n                    <jats:italic>in vitro<\/jats:italic>\n                    , leukocytes from Anx\u20101\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice had reduced cell surface CD 11b (MAC\u20101) but enhanced CD62L (L\u2010selectin) expression and Anx\u20101\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    macrophages exhibited anomalies in phagocytosis. There are also gender differences in activated leukocyte behavior in the Anx\u20101\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice that are not seen in the wild\u2010type animals, suggesting an interaction between sex hormones and inflammation in Anx\u20101\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    animals.\n                  <\/jats:p>","DOI":"10.1096\/fj.02-0239fje","type":"journal-article","created":{"date-parts":[[2003,1,28]],"date-time":"2003-01-28T17:25:55Z","timestamp":1043774755000},"page":"253-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":298,"title":["Aberrant inflammation and resistance to glucocorticoids in Annexin 1\n                    <sup>\u2212\/\u2212<\/sup>\n                    Mouse"],"prefix":"10.1096","volume":"17","author":[{"given":"Robert","family":"Hannon","sequence":"first","affiliation":[{"name":"Department of Biochemical Pharmacology William Harvey Research Institute Queen Mary University of London Charterhouse Square EC1M 6BQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie D.","family":"Croxtall","sequence":"additional","affiliation":[{"name":"Department of Biochemical Pharmacology William Harvey Research Institute Queen Mary University of London Charterhouse Square EC1M 6BQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Getting","sequence":"additional","affiliation":[{"name":"Department of Biochemical Pharmacology William Harvey Research Institute Queen Mary University of London Charterhouse Square EC1M 6BQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorentina","family":"Roviezzo","sequence":"additional","affiliation":[{"name":"Universita Degli Studi Di Napoli Dipartimento di Farmacologia Sperimentale Federico II Via Domenico Montesano 49 Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Yona","sequence":"additional","affiliation":[{"name":"Department of Biochemical Pharmacology William Harvey Research Institute Queen Mary University of London Charterhouse Square EC1M 6BQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Paul\u2010Clark","sequence":"additional","affiliation":[{"name":"Department of Biochemical Pharmacology William Harvey Research Institute Queen Mary University of London Charterhouse Square EC1M 6BQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicity N. 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