{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:17:54Z","timestamp":1761707874984,"version":"build-2065373602"},"reference-count":40,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:p>\n                    LP\u2010BM5 murine leukemia virus (MuLV) infection causes murine acquired immunodeficiency syndrome (MAIDS), a disease characterized by varied functional abnormalities of immunocompetent cells. We found that MAIDS progression was severely retarded in IL\u201015 transgenic (Tg) mice constructed with cDNA encoding secretable IL\u201015 under the control of an MHC class I promoter. Several immune defects, including impaired natural killer activity, depressed IFN\u2010' production by T cells stimulated with anti\u2010T cell receptor cross\u2010linking, and increased susceptibility to\n                    <jats:italic>Mycobacteium bovis<\/jats:italic>\n                    infection, were prevented in IL\u201015 Tg mice inoculated with LP\u2010BM5 MuLV. Cytotoxic T lymphocyte response to a highly antigenic 10\u2010mer pep\u2010tide encoded by LP\u2010BM5\u2010defective virus gag p12 gene was detected in the spleen and peritoneal exudate cells from IL\u201015 Tg mice infected with LP\u2010BM5 MuLV. Intramuscular injection of cDNA encoding secretable IL\u201015 also prevented the development of MAIDS. These results indicate that IL\u201015 prevents the progression of MAIDS and may provide insight into an immunotherapeutic approach using the IL\u201015 gene for controlling retrovirus\u2010induced immunodeficiency.\u2014Umemura, M., Nishimura, H., Yajima, T., Wajjwalk, W., Matsuguchi, T., Takahashi, M., Nishiyama, Y., Makino, M., Nagai, Y., Yoshikai, Y. Overexpression of interleukin\u201015 prevents the development of murine retrovirus\u2010induced acquired immunodeficiency syndrome.\n                    <jats:italic>FASEB J<\/jats:italic>\n                    . 16, 1755\u20131763 (2002)\n                  <\/jats:p>","DOI":"10.1096\/fj.02-0274com","type":"journal-article","created":{"date-parts":[[2002,10,30]],"date-time":"2002-10-30T13:44:20Z","timestamp":1035985460000},"page":"1755-1763","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Overexpression of interleukin\u201015 prevents the development of murine retrovirus\u2010induced acquired immunodeficiency syndrome"],"prefix":"10.1096","volume":"16","author":[{"given":"Masayuki","family":"Umemura","sequence":"first","affiliation":[{"name":"Laboratory of Host Defense, Research Institute for Disease Mechanism and Control Nagoya University Graduate School of Medicine  Nagoya 466\u20138550 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