{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:15:38Z","timestamp":1792606538664,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,1,22]],"date-time":"2003-01-22T00:00:00Z","timestamp":1043193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Er 223\/5-1"],"award-info":[{"award-number":["Er 223\/5-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:p>\n                    It was the aim of this study to further explore the functional role of vitamin D in the endocrine pancreas. By gene targeting, we have recently generated mice in which a\n                    <jats:italic>lacZ<\/jats:italic>\n                    reporter gene is driven by the endogenous vitamin D receptor (VDR) promoter. These mice express a functionally inactive mutant VDR. Pancreatic islets but not exocrine pancreas cells showed strong\n                    <jats:italic>lacZ<\/jats:italic>\n                    reporter gene expression in mutant mice. To rule out possible influences of hypocalcemia on pancreatic endocrine function, a rescue diet enriched with calcium, phosphorus, and lactose was fed to wild\u2010type (WT) and VDR mutant mice. The rescue diet normalized body weight and mineral homeostasis in VDR mutants. In glucose tolerance tests, baseline blood glucose levels were unchanged in fasting VDR mutants. However, blood glucose was elevated after oral or subcutaneous glucose loading, and maximum serum insulin levels were reduced by ~60% in VDR mutants vs. WT mice on either diet. In addition, insulin mRNA levels were decreased in VDR mutant mice on both diets, whereas pancreatic \u03b2 cell mass, islet architecture, and islet neogenesis were normal. These findings clearly establish a molecular role of the VDR in pancreatic insulin synthesis and secretion in vivo.\n                  <\/jats:p>","DOI":"10.1096\/fj.02-0424fje","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T17:42:07Z","timestamp":1047404527000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":357,"title":["Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor"],"prefix":"10.1096","volume":"17","author":[{"given":"Ute","family":"Zeitz","sequence":"first","affiliation":[{"name":"Institute of Animal Physiology Ludwig Maximilians University 80539 Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Weber","sequence":"additional","affiliation":[{"name":"Institute of Animal Physiology Ludwig Maximilians University 80539 Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desi W.","family":"Soegiarto","sequence":"additional","affiliation":[{"name":"Institute of Mammalian Genetics GSF National Research Center for Environment and Health 85758 Neuherberg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckhard","family":"Wolf","sequence":"additional","affiliation":[{"name":"Institute of Molecular Animal Breeding Ludwig Maximilians University 81377 Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudi","family":"Balling","sequence":"additional","affiliation":[{"name":"Institute of Mammalian Genetics GSF National Research Center for Environment and Health 85758 Neuherberg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhold G.","family":"Erben","sequence":"additional","affiliation":[{"name":"Institute of Animal Physiology Ludwig Maximilians University 80539 Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,1,22]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1155","volume-title":"In Williams Textbook of Endocrinology","author":"Bringhurst F. R.","year":"1998"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3283939"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a022662"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.3.325"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1998.78.4.1193"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6250216"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-119-1-84"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-120-4-1490"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1600087"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3177\/jnsv.46.115","article-title":"Oral glucose tolerance is unaltered in vitamin D\u2010deficient rat","volume":"46","author":"Ayesha I.","year":"2000","journal-title":"J. Nutr. Sci. Vitaminol. (Tokyo)"},{"key":"e_1_2_6_12_1","first-page":"78","article-title":"Vitamin D deficiency reduces insulin secretion and turnover in rats","volume":"14","author":"Ayesha I.","year":"2001","journal-title":"Diabetes Nutr. Metab."},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1210\/endo.134.4.8137721","article-title":"1,25\u2010dihydroxyvitamin D3 and pancreatic \u03b2\u2010cell function: vitamin D receptors, gene expression, and insulin secretion","volume":"134","author":"Lee S.","year":"1994","journal-title":"Endocrinology"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050776"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.00985.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.3.504"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s001250051112","article-title":"Vitamin D supplement in early childhood and risk for Type I (insulin\u2010 dependent) diabetes mellitus","volume":"42","author":"The EURODIAB Substudy 2 Study Group","year":"1999","journal-title":"Diabetologia"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06580-1"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend.16.7.0866"},{"key":"e_1_2_6_20_1","first-page":"181","volume-title":"In Gene Targeting: A Practical Approach","author":"Gossler A.","year":"1993"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.12.2270"},{"key":"e_1_2_6_22_1","doi-asserted-by":"crossref","first-page":"E356","DOI":"10.1152\/ajpendo.1994.267.3.E356","article-title":"Immunohistochemical localization of the 1,25(OH)2D3 receptor and calbindin D28k in human and rat pancreas","volume":"267","author":"Johnson J. A.","year":"1994","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"e_1_2_6_23_1","first-page":"973","volume-title":"In Williams Textbook of Endocrinology","author":"Unger R. H.","year":"1998"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.18.9831"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.10.6262"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.6.7567"},{"key":"e_1_2_6_27_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1210\/jcem-60-1-57","article-title":"Does 1,25\u2010dihydroxyvitamin D participate in the regulation of hormone release from endocrine glands?","volume":"60","author":"Hochberg Z.","year":"1985","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmr.5610080206"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.02-0424fje","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.02-0424fje","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.02-0424fje","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:01:32Z","timestamp":1761670892000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.02-0424fje"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1,22]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["10.1096\/fj.02-0424fje"],"URL":"https:\/\/doi.org\/10.1096\/fj.02-0424fje","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1,22]]},"assertion":[{"value":"2002-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-11-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-01-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}