{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:17:51Z","timestamp":1790918271608,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2003,2,5]],"date-time":"2003-02-05T00:00:00Z","timestamp":1044403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Engagement of the B cell receptor antigen (BCR) triggers apoptosis on immature B cell lines. We report here that BCR triggering leads to caspase activation followed by Lyn cleavage and induction of apoptosis. The cleavage process is mitochondrion\u2010dependent and involves caspases 9 and 7. Stable expression of the cleaved form of Lyn (Lyn\u2010\u0394\u2010N) in Ramos B cells impairs BCR\u2010mediated apoptosis as judged by loss of \u0394\u03c8m, caspase activation and PARP cleavage. Activation of the main survival pathways upon BCR\u2010triggering was unaltered in both cell variants. However, the PI3\u2010K inhibitor Ly294002 resensitizes Lyn\u2010\u0394\u2010N cells to apoptosis. Selected cDNA expression arrays revealed that anti\u2010IgM modulates the expression of \u223c20 genes in both cell variants. Among them, only c\u2010Myc was found to be differentially regulated, which suggests a role for c\u2010Myc in the B cell apoptotic response. Interestingly, c\u2010Myc expression decreased more rapidly in Lyn\u2010\u0394\u2010N compared with Lyn\u2010WT cells during the first hours of anti\u2010IgM stimulation. Nevertheless, rapid down\u2010regulation of c\u2010Myc following BCR engagement seems to correlate with the resistance of B cells to apoptosis. Thus, the soluble form of Lyn generated by caspases following BCR triggering acts as an inhibitor of B lymphocyte death likely through the modulation of c\u2010Myc expression.<\/jats:p>","DOI":"10.1096\/fj.02-0716fje","type":"journal-article","created":{"date-parts":[[2003,3,28]],"date-time":"2003-03-28T21:03:22Z","timestamp":1048885402000},"page":"711-713","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The P54\u2010cleaved form of the tyrosine kinase Lyn generated by caspases during BCR\u2010induced cell death in B lymphoma acts as a negative regulator of apoptosis"],"prefix":"10.1096","volume":"17","author":[{"given":"Frederic","family":"Luciano","sequence":"first","affiliation":[{"name":"INSERM U526 Activation des Cellules Hematopoietiques\/Physiopathologie de la Survie et de la Mort Cellulaires et Infections Virales Equipe Labellis\u00e9e par la Ligue Nationale contre le Cancer IFR50 Facult\u00e9 de M\u00e9decine Avenue de Valombrose 06107 Nice\u2010Cedex 2 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Herrant","sequence":"additional","affiliation":[{"name":"INSERM U526 Activation des Cellules Hematopoietiques\/Physiopathologie de la Survie et de la Mort Cellulaires et Infections Virales Equipe Labellis\u00e9e par la Ligue Nationale contre le Cancer IFR50 Facult\u00e9 de M\u00e9decine Avenue de Valombrose 06107 Nice\u2010Cedex 2 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Jacquel","sequence":"additional","affiliation":[{"name":"INSERM U526 Activation des Cellules Hematopoietiques\/Physiopathologie de la Survie et de la Mort Cellulaires et Infections Virales Equipe Labellis\u00e9e par la Ligue Nationale contre le Cancer IFR50 Facult\u00e9 de M\u00e9decine Avenue de Valombrose 06107 Nice\u2010Cedex 2 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Ehrland","family":"Ricci","sequence":"additional","affiliation":[{"name":"Cellular Immunology La Jolla Institute for Allergy and Immunology 10355 Science Center Drive San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Auberger","sequence":"additional","affiliation":[{"name":"INSERM U526 Activation des Cellules Hematopoietiques\/Physiopathologie de la Survie et de la Mort Cellulaires et Infections Virales Equipe Labellis\u00e9e par la Ligue Nationale contre le Cancer IFR50 Facult\u00e9 de M\u00e9decine Avenue de Valombrose 06107 Nice\u2010Cedex 2 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,2,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80029-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(99)80025-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2000.00609.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2478(02)00017-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(00)00205-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100380050029"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7878464"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/35037710"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(97)01085-2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202581"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5381.1312"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.29.20049"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.12.7141"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200001)30:1<69::AID-IMMU69>3.0.CO;2-#"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"4655","DOI":"10.4049\/jimmunol.163.9.4655","article-title":"Mitochondria connects the antigen receptor to effector caspases during B cell receptor\u2010induced apoptosis in normal human B cells","volume":"163","author":"Berard M.","year":"1999","journal-title":"J. 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