{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:18:04Z","timestamp":1768436284684,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2003,4,22]],"date-time":"2003-04-22T00:00:00Z","timestamp":1050969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G9900376"],"award-info":[{"award-number":["G9900376"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Following injury or infection, the liver releases acute\u2010phase proteins (APP). After a severe focal injury, this systemic response can be excessive and may lead to multiorgan dysfunction (MODS). CINC\u20101 is a neutrophil chemoattractant, and we have now established that it also functions as an early APP after injury to the brain or to peripheral tissues. After induction of a focal inflammatory lesion in the brain, there is rapid hepatic and serum CINC\u20101 induction, which is associated with increases in neutrophil numbers within the liver and within the circulation. CINC\u20101\u2010mediated recruitment of neutrophils to organs distant from the primary injury site may contribute to MODS. Indeed, we found that enzyme markers of liver tissue injury are increased in the serum following generation of a focal inflammatory lesion in the brain. Neutralization of CINC\u20101 in the periphery reversed brain\u2010injury\u2010induced neutrophil mobilization and inhibited recruitment of neutrophils to the brain and to the liver. Thus, a significant component of the hepatic acute\u2010phase response is the release of chemokines by the liver, which act to amplify the inflammatory response and modulate the subsequent leukocytosis and secondary tissue damage. Hepatic CINC\u20101 synthesis following injury presents a novel focus for treatment of inflammation.<\/jats:p>","DOI":"10.1096\/fj.02-0757fje","type":"journal-article","created":{"date-parts":[[2003,4,28]],"date-time":"2003-04-28T20:13:44Z","timestamp":1051560824000},"page":"1168-1170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":123,"title":["CINC\u20101 is identified as an acute\u2010phase protein induced by focal brain injury causing leukocyte mobilization and liver injury"],"prefix":"10.1096","volume":"17","author":[{"given":"Sandra J.","family":"Campbell","sequence":"first","affiliation":[{"name":"Molecular Neuropathology Laboratory School of Biological Sciences University of Southampton Biomedical Sciences Building Southampton S016 7PX UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula M.","family":"Hughes","sequence":"additional","affiliation":[{"name":"CNS Inflammation Group School of Biological Sciences University of Southampton Biomedical Sciences Building Southampton S016 7PX UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Iredale","sequence":"additional","affiliation":[{"name":"Tissue Remodelling and Repair, Hepatology School of Medicine University of Southampton Tremona Road Southampton SO16 6YD UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Wilcockson","sequence":"additional","affiliation":[{"name":"CNS Inflammation Group School of Biological Sciences University of Southampton Biomedical Sciences Building Southampton S016 7PX UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Waters","sequence":"additional","affiliation":[{"name":"CNS Inflammation Group School of Biological Sciences University of Southampton Biomedical Sciences Building Southampton S016 7PX UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Docagne","sequence":"additional","affiliation":[{"name":"Molecular Neuropathology Laboratory School of Biological Sciences University of Southampton Biomedical Sciences Building Southampton S016 7PX UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Hugh Perry","sequence":"additional","affiliation":[{"name":"CNS Inflammation Group School of Biological Sciences University of Southampton Biomedical Sciences Building Southampton S016 7PX UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel C.","family":"Anthony","sequence":"additional","affiliation":[{"name":"Molecular Neuropathology Laboratory School of Biological Sciences University of Southampton Biomedical Sciences Building Southampton S016 7PX UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,4,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2000.tb00247.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00136.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(92)90033-T"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1996.13.333"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(07)00373-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.01166.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(96)00252-7"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.65.6.744"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.137.10.4503"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.9604"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051915"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250322"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.56.5.559"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902113400607"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000026388"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200203000-00009"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1994.11.447"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199903000-00026"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.8.2007121"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000049502"},{"key":"e_1_2_6_22_1","first-page":"279","article-title":"Biological activity and brain actions of recombinant rat interleukin- 1alpha and interleukin-1beta","volume":"9","author":"Anforth H. 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