{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:24:35Z","timestamp":1790864675479,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2003,3,5]],"date-time":"2003-03-05T00:00:00Z","timestamp":1046822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013415","name":"Conseil R\u00e9gional Midi-Pyr\u00e9n\u00e9es","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007391","name":"Association pour la Recherche sur le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007391","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lymphocyte emigration from the blood into most secondary lymphoid organs and chronically inflamed tissues occurs at the level of high endothelial venules (HEV). A unique characteristic of HEV endothelial cells (HEVEC) is their capacity to incorporate large amounts of sulfate into sialomucin\u2010type counter\u2010receptors for the lymphocyte homing receptor L\u2010selectin. We have previously shown that sulfate uptake into HEVEC is mediated by two distinct functional classes of sulfate transporters: Na\n                    <jats:sup>+<\/jats:sup>\n                    \u2010coupled transporters and sulfate\/anion exchangers. Here, we report the molecular characterization from human HEVEC of SLC26A11, a novel member of the SLC26 sulfate\/anion exchanger family. Functional expression studies in COS\u20107 and Sf9 insect cells revealed that SLC26A11 is targeted to the cell membrane and exhibits Na\n                    <jats:sup>+<\/jats:sup>\n                    \u2010independent sulfate transport activity, sensitive to the anion exchanger inhibitor 4,4\u2032\u2010diisothiocyanostilbene\u20102,2\u2032\u2010disulfonic acid (DIDS). Northern blot analysis showed the highest SLC26A11 transcript levels in placenta, kidney, and brain. The SLC26A11 gene mapped to human chromosome 17q25, very close to the hereditary hearing loss diseases loci DFNA20, DFNA26, and USH1G. RT\u2010PCR analysis of SLC26 sulfate transporters in human HEVEC revealed coexpression of SLC26A11 with SLC26A2\/DTDST and lack of SLC26A1\/SAT1, SLC26A3\/DRA, and SLC26A8\/TAT1. Together, our results indicate that SLC26A11 is a novel Na\n                    <jats:sup>+<\/jats:sup>\n                    \u2010independent sulfate transporter that may cooperate with SLC26A2 to mediate DIDS\u2010sensitive sulfate uptake into HEVEC.\n                  <\/jats:p>","DOI":"10.1096\/fj.02-0787fje","type":"journal-article","created":{"date-parts":[[2003,4,30]],"date-time":"2003-04-30T16:03:40Z","timestamp":1051718620000},"page":"1-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Molecular and functional characterization of SLC26A11, a sodium\u2010independent sulfate transporter from high endothelial venules"],"prefix":"10.1096","volume":"17","author":[{"given":"Jean-Baptiste","family":"Vincourt","sequence":"first","affiliation":[{"name":"Laboratoire de Biologie Vasculaire Institut de Pharmacologie et de Biologie Structurale du CNRS  31077 Toulouse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Jullien","sequence":"additional","affiliation":[{"name":"ENDOCUBE  31312 Lab\u00e8ge Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Amalric","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Vasculaire Institut de Pharmacologie et de Biologie Structurale du CNRS  31077 Toulouse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Girard","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Vasculaire Institut de Pharmacologie et de Biologie Structurale du CNRS  31077 Toulouse"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,3,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5258.60"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(95)80023-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1242\/jcs.57.1.277","article-title":"Migration of lymphocytes across specialized vascular endothelium. 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