{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:27:36Z","timestamp":1761694056007,"version":"build-2065373602"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2003,3,28]],"date-time":"2003-03-28T00:00:00Z","timestamp":1048809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Recently, we reported the cloning and preliminary characterization of a novel human immunomodulator named PLIF (placenta immunomodulatory ferritin). PLIF has a unique molecular structure, which is composed of a ferritin heavy chain\u2010like domain and a novel cytokine\u2010like domain called C48. Both intact molecule and C48 inhibit T cell proliferation following allogeneic or anti\u2010CD3 stimuli. PLIF is localized at the fetal\u2010maternal interface of human placenta and might play a role in down\u2010modulating the maternal immune reaction toward the embryo. The inhibitory effect of PLIF on T cell activation can be direct, indirect through cytokine mediators, or both. In the present study we investigated the possible indirect effects of PLIF by using its bioactive domain C48. Measurement of various cytokines revealed that C48, predominantly, induce pronounced and rapid IL\u201010 production in monocytes, which is immune activation\u2010independent. Further, we discovered that C48\u2010induced IL\u201010 production is mediated through a calcium\/calmodulin\u2010p38 mitogen\u2010activated protein (MAP) kinase signaling pathway. However, extracellular signal\u2010related kinases1,2 (ERK1,2), also activated by C48 stimulation, exhibited a limiting effect on IL\u201010 production.<\/jats:p>","DOI":"10.1096\/fj.02-0960fje","type":"journal-article","created":{"date-parts":[[2003,4,30]],"date-time":"2003-04-30T16:03:40Z","timestamp":1051718620000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["PLIF induces IL\u201010 production in monocytes: a calmodulin\u2010p38 mitogen\u2010activated protein kinase\u2010dependent pathway"],"prefix":"10.1096","volume":"17","author":[{"given":"Muayad A.","family":"Zahalka","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Immunology Felsenstein Medical Research Center Sackler School of Medicine Tel Aviv University Rabin Medical Center  Petach-Tikva 49100 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian","family":"Barak","sequence":"additional","affiliation":[{"name":"Immunology-Oncology Laboratory Hadassah Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonid","family":"Traub","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology Felsenstein Medical Research Center Sackler School of Medicine Tel Aviv University Rabin Medical Center  Petach-Tikva 49100 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaya","family":"Moroz","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology Felsenstein Medical Research Center Sackler School of Medicine Tel Aviv University Rabin Medical Center  Petach-Tikva 49100 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,3,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200956200"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.5.1209"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1269"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1979.tb01142.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.9.3326"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M011157200"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.6.3339"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.4.2202"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.4049\/jimmunol.149.7.2378","article-title":"IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells","volume":"149","author":"Yassel H.","year":"1992","journal-title":"J. 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