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LPA stimulates proliferation of ovarian cancer cells and has been proposed as an autocrine growth factor. Here, we show that a novel autocrine loop of LPA promotes the migration of ovarian cancer cells, which is a critical step of tumor metastasis. We report that laminin, but not other extracellular matrix proteins, induces LPA production in ovarian cancer cells. A neutralizing antibody against \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    integrin and a calcium\u2010independent phospholipase A\n                    <jats:sub>2<\/jats:sub>\n                    \u2010specific inhibitor, HELSS, block both LPA production and the haptotactic activity of laminin. Exogenously added LPA restores the migratory ability of HEY ovarian cancer cells to laminin. These data suggest that laminin\u2010induced cell migration is mediated by LPA. We further show that a specific receptor for LPA, LPA\n                    <jats:sub>3<\/jats:sub>\n                    , is required for mediating the chemotactic activity of LPA. In addition, we show that cytosolic PLA\n                    <jats:sub>2<\/jats:sub>\n                    is required for cell migration and its activation is phosphatidylinositol\u20103 kinase\u2010dependent. These findings have revealed a new mechanism of crosstalk between a \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    integrin receptor and a G protein\u2010coupled receptor.\n                  <\/jats:p>","DOI":"10.1096\/fj.02-1145fje","type":"journal-article","created":{"date-parts":[[2003,7,29]],"date-time":"2003-07-29T16:11:57Z","timestamp":1059495117000},"page":"1-24","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["A novel laminin\u2010induced lysophosphatidic acid autocrine loop in the migration of ovarian cancer cells"],"prefix":"10.1096","volume":"17","author":[{"given":"Saubhik","family":"Sengupta","sequence":"first","affiliation":[{"name":"Department of Cancer Biology The Lerner Research Institute Cleveland Clinic Foundation  9500 Euclid Avenue Cleveland OHIO 44195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology The Lerner Research Institute Cleveland Clinic Foundation  9500 Euclid Avenue Cleveland OHIO 44195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology The Lerner Research Institute Cleveland Clinic Foundation  9500 Euclid Avenue Cleveland OHIO 44195"},{"name":"Department of Gynecology and Obstetrics The Cleveland Clinic Foundation  9500 Euclid Avenue Cleveland OHIO 44195"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,6,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19960904)67:5<695::AID-IJC18>3.0.CO;2-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/07357909809039774"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.102.4.639"},{"key":"e_1_2_6_5_1","first-page":"10","article-title":"Cancer metastasis and adhesion molecules","volume":"312","author":"Miyasaka M.","year":"1995","journal-title":"Clin. 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