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The \u03b2\u2010amyloid peptide (A\u03b2) is centrally related to the pathogenesis of AD, and previous reports have demon\u00acstrated that the blockade of glutamate receptors pre\u00acvents A\u03b2\u2010induced neuronal death. We show that tau\u00acrine, a \u03b2\u2010amino acid found at high concentrations in the brain, protects chick retinal neurons in culture against the neurotoxicity of A\u03b2 and glutamate receptor ago\u00acnists. The protective effect of taurine is not mediated by interaction with glutamate receptors, as demon\u00acstrated by binding studies using radiolabeled glutamate receptor ligands. The neuroprotective action of taurine is blocked by picrotoxin, an antagonist of GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptors. GABA and the GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptor agonists phenobarbital and melatonin also protect neurons against A\u03b2 \u2010induced neurotoxicity. These results suggest that activation of GABA receptors decreases neuronal vulnerability to excitotoxic damage and that pharmaco\u00aclogical manipulation of the excitatory and inhibitory neurotransmitter tonus may protect neurons against a variety of insults. GABAergic transmission may repre\u00acsent a promising target for the treatment of AD and other neurological disorders in which excitotoxicity plays a relevant role.\u2014Louzada, P. R., Lima, A. C. P., Mendonca\u2010Silva, D. L., No\u00ebl, F., de Mello, F. G., Ferreira, S. T. Taurine prevents the neurotoxicity of \u03b2\u2010amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alz\u00acheimer's disease and other neurological disorders.\n                  <\/jats:p>","DOI":"10.1096\/fj.03-0739com","type":"journal-article","created":{"date-parts":[[2004,3,4]],"date-time":"2004-03-04T20:48:42Z","timestamp":1078433322000},"page":"511-518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":216,"title":["Taurine prevents the neurotoxicity of \u03b2\u2010amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders"],"prefix":"10.1096","volume":"18","author":[{"given":"Paulo Roberto","family":"Louzada","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica M\u00e9dica Universidade Federal do Rio de Janeiro Rio de Janeiro RJ 21941\u2010590 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a C. 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