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We propose that the balance of stimulators and inhibitors, as well as the general sensitivity of the endothelium to these factors, varies from individual to individual. Indeed, we have found that individual mouse strains have dramatically different responses to growth factor\u2010induced neovascularization. Quantitative trait loci (QTLs), which influence the extent of angiogenesis induced by vascular endothelial growth factor (VEGF), were previously identified by our laboratory. Since genetic susceptibility may vary according to the angiogenic stimulator, we have undertaken a similar mapping approach to identify QTLs that influence basic fibroblast growth factor (FGF2) induced neovascularization in the BXD series of recombinant inbred mouse strains. Composite and multiple interval mapping identified areas of chromosomes 4, 13, 15, and 18. These new angiogenesis QTLs, named\n                    <jats:italic>AngFq1<\/jats:italic>\n                    through\n                    <jats:italic>AngFq4<\/jats:italic>\n                    (for angiogenesis due to FGF2), are different from previously identified VEGF QTLs. The mapped regions contain several genes involved in the angiogenic process including matrix metalloproteinase 16, eph receptor A7, angiopoetin 1, endothelial lipase, and autotaxin. Differences in these regions may influence individual susceptibility to angiogenesis related diseases such as cancer, macular degeneration, atherosclerosis, and arthritis.\u2014Rogers, M. S., Rohan, R. M., D'Amato, R. J. Genetic loci that control the angiogenic response to basic fibroblast growth factor.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    18, 1050\u20131059 (2004)\n                  <\/jats:p>","DOI":"10.1096\/fj.03-1241com","type":"journal-article","created":{"date-parts":[[2004,6,28]],"date-time":"2004-06-28T18:08:18Z","timestamp":1088446098000},"page":"1050-1059","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Genetic loci that control the angiogenic response to basic response to basic fibroblast growth factor"],"prefix":"10.1096","volume":"18","author":[{"given":"Michael S.","family":"Rogers","sequence":"first","affiliation":[{"name":"Vascular Biology Program, Children's Hospital, and Department of Ophthalmology Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Rohan","sequence":"additional","affiliation":[{"name":"Vascular Biology Program, Children's Hospital, and Department of Ophthalmology Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E.","family":"Birsner","sequence":"additional","affiliation":[{"name":"Vascular Biology Program, Children's Hospital, and Department of Ophthalmology Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"D'amato","sequence":"additional","affiliation":[{"name":"Vascular Biology Program, Children's Hospital, and Department of Ophthalmology Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,7,1]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0246fje"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.14.7.871"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.24.4.245.8412"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-2254(200105\/06)3:3<252::AID-JGM185>3.0.CO;2-S"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01189-3"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.58.070189.003043"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/121.1.185"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1360-1385(96)80040-9"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/136.4.1457"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.23.10972"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/152.3.1203"},{"key":"e_1_2_5_13_1","first-page":"1625","article-title":"A model of angiogenesis in the mouse cornea","volume":"37","author":"Kenyon B. 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