{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:03:15Z","timestamp":1771549395592,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["RO1-HL51018"],"award-info":[{"award-number":["RO1-HL51018"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["R37-HL28373"],"award-info":[{"award-number":["R37-HL28373"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Matrix metalloproteinase\u20102 (MMP\u20102;gelatinase A) is known to degrade a broad range of extracellular matrix components and chemokines, and has important roles in the processes of cell migration, invasion, and involution during development, as well as during tumor growth and metastasis and in inflammation and repair. To better elucidate the roles of this matrix metalloproteinase in the development and progression of experimental autoimmune encephalomyelitis, we used MMP\u20102\u2010deficient (KO) mice. Surprisingly, we found that MMP\u20102 KO mice exhibited an earlier onset and more severe disease than did their wild\u2010type (WT) counterparts. WT mice engrafted with MMP\u20102 KO bone marrow exhibited a similar earlier onset and more severe clinical disease score than WT mice engrafted with WT bone marrow. Lymphocytes derived from MMP\u20102 KO mice exhibited increased transmigration through endothelial cell monolayers as well as through collagen type IV and laminin\u2010coated BD BIOCOAT inserts\n                    <jats:sup>\u00ae<\/jats:sup>\n                    , which correlated with a 3\u2010fold increase in expression of MMP\u20109 and was abrogated by inhibition of MMP activity. We demonstrated a correlation between expression levels of MMP\u20109 and MT1\u2010MMP expression and suggest a signaling pathway involving tethering of MMP\u20102 to MT1\u2010MMP as a modulator of MMP\u20109 expression. Last, we discuss other possible MMP\u20102\u2010mediated mechanisms which may contribute to the observed phenotype.\u2014Esparza, J., Kruse, M., Lee, J., Michaud, M., Madri, J. A. MMP\u20102 null mice exhibit an early onset and severe experimental autoimmune encephalomyelitis due to an increase in MMP\u20109 expression and activity.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    18, 1682\u20131691 (2004)\n                  <\/jats:p>","DOI":"10.1096\/fj.04-2445com","type":"journal-article","created":{"date-parts":[[2004,11,2]],"date-time":"2004-11-02T18:05:44Z","timestamp":1099418744000},"page":"1682-1691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["MMP\u20102 null mice exhibit an early onset and severe experimental autoimmune encephalomyelitis due to an increase in MMP\u20109 expression and activity"],"prefix":"10.1096","volume":"18","author":[{"given":"Jordi","family":"Esparza","sequence":"first","affiliation":[{"name":"Department of Pathology Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghan","family":"Kruse","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Michaud","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph A.","family":"Madri","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5258.60"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.156.1.1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2000\/79045"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.17.1.463"},{"key":"e_1_2_5_6_1","first-page":"1445","article-title":"The interrelationship of alpha4 integrin and matrix metalloproteinase-2 in the pathogenesis of experimental autoimmune encephalomyelitis","volume":"78","author":"Graesser D.","year":"1998","journal-title":"Lab. 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