{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:58:15Z","timestamp":1772895495061,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,4,25]],"date-time":"2005-04-25T00:00:00Z","timestamp":1114387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL67321"],"award-info":[{"award-number":["HL67321"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL071106"],"award-info":[{"award-number":["HL071106"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL55301"],"award-info":[{"award-number":["HL55301"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL64063"],"award-info":[{"award-number":["HL64063"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL67663"],"award-info":[{"award-number":["HL67663"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005963","name":"LAM Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Lymphangioleiomyomatosis (LAM) is a rare disease that occurs primarily in women and has been linked to both estrogen\u2010mediated signaling events and mutations associated with the tuberous sclerosis complex 2 gene product tuberin. These two observations fostered the hypothesis that tuberin's impact on estrogen\u2010mediated signaling might be through a direct interaction with the intracellular receptor for estrogen, estrogen receptor \u03b1 (ER\u03b1). In the study presented here, tuberin was shown to co\u2010immunoprecipitate and directly bind ER\u03b1 through a domain localized within the carboxyl 73 amino acids of tuberin. This domain had previously been shown to serve as a binding domain for the intracellular calcium signaling molecule calmodulin (CaM). Competition binding studies identified a potential competitive relationship for binding of tuberin by ER\u03b1 and CaM. Additionally, tuberin\u2010ER\u03b1 interactions were found to be modulated by the presence of tuberin's predominant intracellular binding partner hamartin, suggesting that tuberin\u2010hamartin interactions negatively impact the ability of tuberin to modulate ER\u03b1\u2010mediated gene transcription events. Cumulatively, data presented here support the hypothesis that interactions between tuberin, ER\u03b1, and CaM may play a critical role in the pathology of LAM disease.<\/jats:p>","DOI":"10.1096\/fj.04-3142fje","type":"journal-article","created":{"date-parts":[[2005,4,25]],"date-time":"2005-04-25T20:25:17Z","timestamp":1114460717000},"page":"1202-1204","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Cross\u2010talk between tuberin, calmodulin, and estrogen signaling pathways"],"prefix":"10.1096","volume":"19","author":[{"given":"Brian","family":"York","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Biochemistry University of Kentucky  Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingyuan","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biochemistry University of Kentucky  Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Reynold A.","family":"Panettieri","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera P.","family":"Krymskaya","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas C.","family":"Vanaman","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biochemistry University of Kentucky  Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Noonan","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biochemistry University of Kentucky  Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,4,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.3_suppl.56S"},{"key":"e_1_2_6_3_1","volume-title":"Tuberous Sclerosis","author":"Gomez M. R.","year":"1988"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1994.tb01881.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-1809.2003.00012.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/35010550"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.32.20535"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00129785-200404010-00003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.8.4686"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.16.5.947"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2001.2682"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.50.33817"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010238200"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(79)91932-6"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)33231-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401912200"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90339-9"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1478-1336-1-7","article-title":"A neuronal\u2010specific differentiation protein that directly modulates retinoid receptor transcriptional activation","volume":"1","author":"Henry K. W.","year":"2003","journal-title":"Nuclear Receptor"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202678200"},{"key":"e_1_2_6_20_1","volume-title":"Short Protocols in Molecular Biology","author":"Ausubel F. M.","year":"1992"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C100136200"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205838200"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb839"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcbr.2001.0307"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","unstructured":"Yu J. Astrinidis A. Howard S. andHenske E. P.(2003)Estradiol and Tamoxifen Stimulate Lymphangiomyomatosis\u2010Associated Angiomyolipoma Cell Growth and Activate Both Genomic and Non\u2010Genomic Signaling Pathways.Am J Physiol Lung Cell Mol Physiol","DOI":"10.1152\/ajplung.00204.2003"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004390000348"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0898-6568(03)00040-8"},{"key":"e_1_2_6_28_1","volume-title":"Calcium as a cellular regulator","author":"Carafoli E.","year":"1999"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210708200"},{"key":"e_1_2_6_30_1","volume-title":"New Prospectives in Tuberous Sclerosis Complex p. A6.6","author":"Roberts P. S.","year":"2002"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026068017309"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9861(02)00300-4"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/35035131"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(20000401)86:1<30::AID-IJC5>3.0.CO;2-I"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(02)00288-5"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.25.2889"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.278.5.F737"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.04-3142fje","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.04-3142fje","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.04-3142fje","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T01:19:28Z","timestamp":1761700768000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.04-3142fje"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,25]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["10.1096\/fj.04-3142fje"],"URL":"https:\/\/doi.org\/10.1096\/fj.04-3142fje","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,25]]},"assertion":[{"value":"2004-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-03-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-04-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}