{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T15:42:54Z","timestamp":1775749374526,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Scavenger receptor class B type I (SR\u2010BI) has been shown to be expressed in human atherosclerotic plaque macrophages, where it is believed to reduce atherosclerosis by promoting cholesterol efflux. In this study we investigated the influence of aspirin and other NSAIDs on SR\u2010BI expression and function in cultured human macrophages as well as in different mouse strains. Incubation of human macrophages with 0.5 mmol\/l aspirin resulted in increased SR\u2010BI protein expression and increased uptake of HDL\u2010associated [\n                    <jats:sup>3<\/jats:sup>\n                    H]cholesteryl oleate without changes of SR\u2010BI mRNA levels. In contrast, using 5 mmol\/l of aspirin, SR\u2010BI expression and function were significantly decreased. Sodium salicylate exerted similar effects on SR\u2010BI expression, whereas no effects were observed using known COX1\/2 inhibitors ibuprofen and naproxen, respectively. In\n                    <jats:italic>in vivo<\/jats:italic>\n                    studies low\u2010dose aspirin treatment (6 mg\/kg\u00b7day) induced SR\u2010BI expression in wild\u2010type and PPAR\u2010\u03b1 knockout mice, respectively, whereas the opposite effect was observed upon high\u2010dose aspirin treatment (60 mg\/kg\u00b7day) in these animals. We could show that COX\u2010independent effects of aspirin were able to enhance expression of SR\u2010BI in macrophages in a post\u2010transcriptional, PPAR\u2010\u03b1 independent way, suggesting a novel pharmacologic effect of aspirin.\u2014Tancevski, I., Wehinger, A., Schgoer, W., Eller, P., Cuzzocrea, S., Foeger, B., Patsch, J. R., Ritsch, A. Aspirin regulates expression and function of scavenger receptor\u2010BI in macrophages: studies in primary human macrophages and in mice.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    20, 1328\u20131335 (2006)\n                  <\/jats:p>","DOI":"10.1096\/fj.05-5368com","type":"journal-article","created":{"date-parts":[[2006,6,30]],"date-time":"2006-06-30T18:17:00Z","timestamp":1151691420000},"page":"1328-1335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Aspirin regulates expression and function of scavenger receptor\u2010BI in macrophages: studies in primary human macrophages and in mice"],"prefix":"10.1096","volume":"20","author":[{"given":"Ivan","family":"Tancevski","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Innsbruck Medical University  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Weliinger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Innsbruck Medical University  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilfried","family":"Schgoer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Innsbruck Medical University  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Eller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Innsbruck Medical University  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Cuzzocrea","sequence":"additional","affiliation":[{"name":"Dipartimento Clinico e Sperimentale di Medicina e di Farmacologia Centro per lo Studio ed il Trattamento dei Neurolesi Lungodegenti Facolt\u00e0 di Medicina e Chirurgia Universit\u00e0 di Messina  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Foeger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Innsbruck Medical University  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef R.","family":"Patsch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Innsbruck Medical University  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Ritsch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Innsbruck Medical University  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5248.518"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"18929","DOI":"10.1016\/S0021-9258(17)46716-0","article-title":"Identification, primary structure, and distribution of CLA-1, a novel member of the CD36\/LIMPII gene family","volume":"268","author":"Calvo D.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.52.33068"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.34.20982"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI14011"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.20.2411"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.85.1.108"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.10.1206"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.35.040195.002313"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/bmj.308.6921.81","article-title":"Collaborative overview of randomised trials of antiplatelet therapy-\u012a: prevention of death, myocardial infarction, and stroke byprolonged antiplatelet therapy in various categories of patients","volume":"308","author":"Antiplatelet Trialists' Collaboration","year":"1994","journal-title":"Br. Med. J."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0224fje"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(84)90278-3"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-005-0695-8"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M300353-JLR200"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0022-2275(20)36783-3","article-title":"Separation of the main lipoprotein density classes from human plasma by rate-zonal ultracentrifugation","volume":"15","author":"Patsch J. R.","year":"1974","journal-title":"J. Lipid Res."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2001.23307"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.84.9.1085"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700185"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000027816.54430.96"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.11.2731"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.10.155"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200403000-00019"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20632"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0390rev"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.12.024"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:REMD.0000045104.38104.8e"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mol.0000162319.54795.e5"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000160340.72641.87"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)01511-3"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02987-X"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.12.1688"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2000.00065.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.48.34111"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8052854"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.11.6377"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.24.14540"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200406000-00008"},{"key":"e_1_2_6_39_1","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1016\/S0022-2275(20)31525-X","article-title":"Scavenger receptor class B type I affects cholesterol homeostasis by magnifying cholesterol flux between cells and HDL","volume":"42","author":"La Llera-Moya M.","year":"2001","journal-title":"J. Lipid Res."},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.10.5599"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63341-X"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.05-5368com","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.05-5368com","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.05-5368com","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T19:40:47Z","timestamp":1761680447000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.05-5368com"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1096\/fj.05-5368com"],"URL":"https:\/\/doi.org\/10.1096\/fj.05-5368com","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7]]},"assertion":[{"value":"2005-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-02-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}