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Reducing NO levels should be beneficial in sepsis, but NOS inhibitors have had a checkered history in animal models, and one such agent increased mortality in a clinical trial. An alternative approach to reduce NO levels in sepsis is to use an NO scavenger, which should leave sufficient free NO for normal physiological functions. Using a well\u2010established model of bacterial sepsis in\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    , we found that cobinamide, a B\n                    <jats:sub>12<\/jats:sub>\n                    analog and an effective NO scavenger\n                    <jats:italic>in vitro<\/jats:italic>\n                    , dramatically improved fly survival. Cobinamide augmented the effect of an antibiotic and was beneficial even in immune\u2010deficient flies. Cobinamide's mechanism of action appeared to be from reducing NO levels and improving cardiac function.\u2014Broderick, K. 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The nitric oxide scavenger cobinamide profoundly improves survival in a\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    model of bacterial sepsis.\n                    <jats:italic>FASEB J<\/jats:italic>\n                    . 20, 1865\u20131873 (2006)\n                  <\/jats:p>","DOI":"10.1096\/fj.06-5780com","type":"journal-article","created":{"date-parts":[[2006,8,28]],"date-time":"2006-08-28T12:36:06Z","timestamp":1156768566000},"page":"1865-1873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The nitric oxide scavenger cobinamide profoundly improves survival in a\n                    <i>Drosophila melanogaster<\/i>\n                    model of bacterial sepsis"],"prefix":"10.1096","volume":"20","author":[{"given":"Kate E.","family":"Broderick","sequence":"first","affiliation":[{"name":"Departments of Medicine University of California San Diego La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake","family":"Feala","sequence":"additional","affiliation":[{"name":"Departments of Bioengineering University of California San Diego La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"McCulloch","sequence":"additional","affiliation":[{"name":"Departments of Bioengineering University of California San Diego La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Paternostro","sequence":"additional","affiliation":[{"name":"The Burnham Institute for Medical Research La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay S.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Departments of Medicine University of California San Diego La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate B.","family":"Pilz","sequence":"additional","affiliation":[{"name":"Departments of Medicine University of California San Diego La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerry R.","family":"Boss","sequence":"additional","affiliation":[{"name":"Departments of Medicine University of California San Diego La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1084"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","unstructured":"Clancy R. 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