{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:13:41Z","timestamp":1790813621847,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p>\n                    In this study we have characterized the anti\u2010inflammatory profile of a selective melanocortin type 3 receptor (MC3\u2010R) ligand [D\u2010Trp\n                    <jats:sup>8<\/jats:sup>\n                    ]\u2010\u03b3\u2010MSH, validating\n                    <jats:italic>in vitro<\/jats:italic>\n                    results with analyses in mice deficient for this receptor subtype. In wild\u2010type (WT) macrophages, [D\u2010Trp\n                    <jats:sup>8<\/jats:sup>\n                    ]\u2010\u03b3\u2010MSH activated MC3\u2010R (as tested by accumulation of cyclic AMP) and inhibited (~50%) the release of interleukin (IL)\u20101 and the chemokine KC (CXCL1), but was ineffective in cells taken from MC3\u2010R null mice.\n                    <jats:italic>In vivo<\/jats:italic>\n                    , administration of 3\u201330 \u03bcg [D\u2010Trp\n                    <jats:sup>8<\/jats:sup>\n                    ]\u2010\u03b3MSH significantly inhibited leukocyte influx and cytokine production in a model of crystal\u2010induced peritonitis, and these effects were absent in MC3\u2010R null mice or blocked by coadministration of an MC3\u2010R antagonist. Finally, in a model of gouty arthritis, direct injection of urate crystals into the rat joint provoked a marked inflammatory reaction that was significantly inhibited (~70%) by systemic or local administration of [D\u2010Trp\n                    <jats:sup>8<\/jats:sup>\n                    ]\u2010\u03b3\u2010MSH. In conclusion, using an integrated transgenic and pharmacological approach, we provide strong proof of concept for the development of selective MC3\u2010R agonists as novel anti\u2010inflammatory therapeutics.\u2014Getting, S. J., Lam, C. W., Chen, A. S., Grieco, P., Perretti, M. Melanocortin 3 receptors control crystal\u2010induced inflammation.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    20, 2234\u20132241 (2006)\n                  <\/jats:p>","DOI":"10.1096\/fj.06-6339com","type":"journal-article","created":{"date-parts":[[2006,10,31]],"date-time":"2006-10-31T16:51:21Z","timestamp":1162313481000},"page":"2234-2241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Melanocortin 3 receptors control crystal\u2010induced inflammation"],"prefix":"10.1096","volume":"20","author":[{"given":"Stephen J.","family":"Getting","sequence":"first","affiliation":[{"name":"The William Harvey Research Institute London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie W.","family":"Lam","sequence":"additional","affiliation":[{"name":"The William Harvey Research Institute London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Airu S.","family":"Chen","sequence":"additional","affiliation":[{"name":"Merck Research Laboratories Rahway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Grieco","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry and Toxicology Universit\u00e1 di Napoli Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Perretti","sequence":"additional","affiliation":[{"name":"The William Harvey Research Institute London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)01009-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.2000.0725"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.56.1.1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1242\/jcs.114.5.1019","article-title":"The melanocortin 1 receptor is the principal mediator of the effects of agouti signaling protein on mammalian melanocytes","volume":"114","author":"Abdel\u2010Malek Z. 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