{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:12:15Z","timestamp":1791263535178,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T00:00:00Z","timestamp":1173139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T00:00:00Z","timestamp":1173139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS048478"],"award-info":[{"award-number":["NS048478"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA019674"],"award-info":[{"award-number":["DA019674"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:p>\n                    Sphingosine 1\u2010phosphate (S1P) is a bio\u2010active sphingolipid produced by sphingosine kinase (SphK1 and 2). We previously showed that S1P receptors (S1P\n                    <jats:sub>1,<\/jats:sub>\n                    S1P\n                    <jats:sub>2,<\/jats:sub>\n                    and S1P\n                    <jats:sub>3<\/jats:sub>\n                    ) are expressed in hepatic myofibroblasts (hMF), a population of cells that triggers matrix remodeling during liver injury. Here we investigated the function of these receptors in the wound healing response to acute liver injury elicited by carbon tetrachloride, a process that associates hepato\u2010cyte proliferation and matrix remodeling. Acute liver injury was associated with the induction of S1P\n                    <jats:sub>2,<\/jats:sub>\n                    S1P\n                    <jats:sub>3,<\/jats:sub>\n                    SphK1, and SphK2 mRNAs and increased SphK activ\u2010ity, with no change in S1P\n                    <jats:sub>1<\/jats:sub>\n                    expression. Necrosis, inflammation, and hepatocyte regeneration were similar in S1P\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    and wild\u2010type (WT) mice. However, compared with WT mice, S1P\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice displayed reduced accumulation of hMF, as shown by lower induction of smooth muscle \u03b1\u2010actin mRNA and lower induction of TIMP\u20101, TGF\u2010\u03b21, and PDGF\u2010BB mRNAs, overall reflecting reduced activation of remodeling in response to liver injury. The wound healing response was similar in S1P\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    and WT mice.\n                    <jats:italic>In vitrO,<\/jats:italic>\n                    S1P enhanced proliferation of cultured WT hMF, and PDGF\u2010BB further enhanced the mitogenic effect of S1P. In keeping with these findings, PDGF\u2010BB up\u2010regulated S1P\n                    <jats:sub>2<\/jats:sub>\n                    and SphK1 mRNAs, increased SphK activity, and S1P\n                    <jats:sub>2<\/jats:sub>\n                    induced PDGF\u2010BB mRNA. These effects were blunted in S1P\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    cells, and S1P\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    hMF exhibited reduced mitogenic and comitogenic responses to S1P. These results unravel a novel major role of S1P\n                    <jats:sub>2<\/jats:sub>\n                    in the wound healing response to acute liver injury by a mechanism involving enhanced proliferation of hMF. \u2013Serriere\u2010Lanneau, V., Teixeira\u2010Clerc, F., Li, L., Schippers, M., de Wries, W., Julien, B., Tran\u2010Van\u2010Nhieu, J., Manin, S., Poelstra, K., Chun, J., Carpentier, S., Levade, T., Mallat, A., Lotersztajn, S. The sphingosine 1\u2010phosphate receptor S1P\n                    <jats:sub>2<\/jats:sub>\n                    triggers hepatic wound healing.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    21, 2005\u20132013 (2007)\n                  <\/jats:p>","DOI":"10.1096\/fj.06-6889com","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T22:25:26Z","timestamp":1173219926000},"page":"2005-2013","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["The sphingosine 1\u2010phosphate receptor S1P\n                    <sub>2<\/sub>\n                    triggers hepatic wound healing"],"prefix":"10.1096","volume":"21","author":[{"given":"Val\u00e9rie","family":"Serriere-Lanneau","sequence":"first","affiliation":[{"name":"INSERM U841 IMRB Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris 12 Facult\u00e9 de M\u00e9decine Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Teixeira-Clerc","sequence":"additional","affiliation":[{"name":"INSERM U841 IMRB Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris 12 Facult\u00e9 de M\u00e9decine Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Li","sequence":"additional","affiliation":[{"name":"INSERM U841 IMRB Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris 12 Facult\u00e9 de M\u00e9decine Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlies","family":"Schippers","sequence":"additional","affiliation":[{"name":"INSERM U841 IMRB Cr\u00e9teil France"},{"name":"Department of Pharmacokinetics and Drug Delivery University of Groningen Groningen Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willie","family":"de Wries","sequence":"additional","affiliation":[{"name":"INSERM U841 IMRB Cr\u00e9teil France"},{"name":"Department of Pharmacokinetics and Drug Delivery University of Groningen Groningen Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Julien","sequence":"additional","affiliation":[{"name":"INSERM U841 IMRB Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris 12 Facult\u00e9 de M\u00e9decine Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne","family":"Tran-Van-Nhieu","sequence":"additional","affiliation":[{"name":"INSERM U841 IMRB Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris 12 Facult\u00e9 de M\u00e9decine Cr\u00e9teil France"},{"name":"AP\u2010HP, Groupe hospitalier Henri Mondor\u2010Albert Chenevier D\u00e9partement de Pathologie Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Manin","sequence":"additional","affiliation":[{"name":"INSERM U841 IMRB Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris 12 Facult\u00e9 de M\u00e9decine Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaas","family":"Poelstra","sequence":"additional","affiliation":[{"name":"Department of Pharmacokinetics and Drug Delivery University of Groningen Groningen Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerold","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology Helen L. Dorris Child and Adolescent Neuropsychiatric Disorder Institute The Scripps Research Institute La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Carpentier","sequence":"additional","affiliation":[{"name":"LNSERM IFR31 U858 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Levade","sequence":"additional","affiliation":[{"name":"LNSERM IFR31 U858 Toulouse France"},{"name":"Universit\u00e9 Toulouse III Paul Sabatier IFR31 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Mallat","sequence":"additional","affiliation":[{"name":"INSERM U841 IMRB Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris 12 Facult\u00e9 de M\u00e9decine Cr\u00e9teil France"},{"name":"AP\u2010HP, Groupe hospitalier Henri Mondor\u2010Albert Chenevier Service d,H\u00e9patologie et de Gastroent\u00e9rologie Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Lotersztajn","sequence":"additional","affiliation":[{"name":"INSERM U841 IMRB Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris 12 Facult\u00e9 de M\u00e9decine Cr\u00e9teil France"},{"name":"AP\u2010HP, Groupe hospitalier Henri Mondor\u2010Albert Chenevier Service d,H\u00e9patologie et de Gastroent\u00e9rologie Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1103"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3490385"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2004.05.002"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1650"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2004.01.006"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.73.011303.073731"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.41.1.507"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10905"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81661-X"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200422716"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200418004"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311743200"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501997102"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.10.4237-4249.2005"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M006393200"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202798200"},{"key":"e_1_2_5_18_1","first-page":"G1091","article-title":"Characterization of sphingosine 1-phos-phate-induced actions and its signaling pathways in rat hepato-cytes","volume":"272","author":"Im D. S.","year":"1997","journal-title":"Am. J. Physiol."},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50049"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20967"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.04.207"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200137200"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104441200"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1421"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.12.050"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00906-5"},{"key":"e_1_2_5_27_1","doi-asserted-by":"crossref","first-page":"38152","DOI":"10.1074\/jbc.M101980200","article-title":"15-Deoxy-delta 12,14-prostaglan-din j2 induces apoptosis of human hepatic myofibroblasts. a pathway involving oxidative stress independently ofperoxisome-proliferator-activated receptors","volume":"276","author":"Li L.","year":"2001","journal-title":"J. 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